acne definition l.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
ACNE Definition PowerPoint Presentation
Download Presentation
ACNE Definition

Loading in 2 Seconds...

play fullscreen
1 / 32

ACNE Definition - PowerPoint PPT Presentation


  • 247 Views
  • Uploaded on

ACNE Definition. Inflammation of sebaceous follicles Follicle sebaceous gland follicular canal hair. ACNE Classification. comedonal acne mild inflammatory acne moderate inflammatory acne severe inflammatory (nodulocystic). ACNE Pathogenesis. Pubertal changes

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

ACNE Definition


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
acne definition
ACNEDefinition
  • Inflammation of sebaceous follicles
  • Follicle
    • sebaceous gland
    • follicular canal
    • hair
acne classification
ACNEClassification
  • comedonal acne
  • mild inflammatory acne
  • moderate inflammatory acne
  • severe inflammatory (nodulocystic)
acne pathogenesis
ACNEPathogenesis
  • Pubertal changes
  • increased sebaceous production of sebum
  • abnormal sloughing of follicular wall lining
  • closed comedone (whitehead)
  • open comedone (blackhead)
acne pathogenesis4
ACNEPathogenesis
  • Accumulation of Propionobacterium acnes (normal skin flora)
  • metabolization of sebum release of free fatty acids
  • attraction of neutrophils  rupture of follicular wall extrusion into the dermis
  • inflammatory lesions
    • papules, pustules
    • nodules, cysts
acne lesions
ACNELesions

Inflammatory and comedonal acne

acne lesions7
ACNELesions

Open comedones are evident on the chin

acne lesions8
ACNELesions

inflammatory and comedonal acne

acne therapy mechanisms
ACNETherapy (Mechanisms)
  • Hormonal regulation
  • Sebum suppression
  • Keratolysis and inhibition of follicular proliferation
  • Antibacterial / antiinflammatory
hormonal regulation
Hormonal regulation
  • Oral contraceptives
    • particularly estrogen predominant
    • Ortho-Tri-Cyclen
  • Spironolactone
sebum suppression
Sebum suppression
  • Isotretinoin (Accutane)
    • oral synthetic Vitamin A analog
    • shrinks sebaceous gland
keratolysis and inhibition of follicular proliferation
Keratolysis and inhibition of follicular proliferation
  • OTC preparations
    • salicylic acid (Stridex)
    • Benzoyl Peroxide
  • Isotretinoin (Accutane)
  • Topical retinoids
    • tretinoin (Retin-A)
    • adapalene (Differin)
    • tazarotene (Tazorac)
  • Azelaic Acid (Azelex)
acne topical retinoids
ACNETopical retinoids

Contemporary Peds Dec. 2000

acne adapalene differin
ACNEAdapalene (Differin)
  • Derivative of Naphthoic acid
  • Has more specific retinoid receptor activity
  • Some studies have shown less irritation
acne azelaic acid azelex
ACNEAzelaic Acid (Azelex)
  • Dicarboxylic acid produced by P. ovale
  • demonstrated activity against P. acne
  • demonstrated ability to inhibit microcomedo
  • Prevents hyperpigmentation
    • inhibits tyrosinase (melanin synthesis)
    • adresses postinflammatory hyperpigmentation
antibacterial antiinflammatory
Antibacterial / antiinflammatory
  • Topical
    • Erythromycin
    • Clindamycin
  • Oral
    • Tetracycline
    • Doxycycline
    • Minocycline
    • Erythromycin
acne topical antibiotics
ACNETopical antibiotics

Contemporary Peds Dec. 2000

acne oral antibiotics
ACNEOral Antibiotics

Contemporary Peds Dec. 2000

acne therapy vehicle effects efficacy
Creams

Less potent than gels

Less drying than gels

May not be good for the patient with oily complexion

Gels, solutions

more drying

tend to cause more irritation

oily skin

ACNEtherapy (vehicle effects efficacy)
acne counseling
ACNECounseling
  • Poor hygiene is not a cause of acne
  • Effect of diet has not been demonstrated
  • 4 – 6 weeks of treatment before any improvement is expected
  • Warn patients about skin irritation
    • BP, topical retinoids
  • Warn patients about photosensitivity
    • topical retinoids, tetracycline, Doxycycine
    • apply at night
    • consider noncomedogenic sunscreen (SPF =15)
acne counseling ii
ACNECounseling II
  • Apply topical therapy to entire region not just to lesion
  • Start at low dose, infrequent applications and increase gradually
  • Apply to thoroughly dried skin
    • 30 minutes of air-drying
    • not right after washing your face
  • Avoid cosmetics, mechanical friction
    • harsh scrubbing
    • tight chin straps, caps
    • bangs
acne treatment plans24
ACNE Treatment Plans

Consultant April 1999

acne when to refer
ACNEWhen to refer
  • No improvement despite therapy
  • Cysts or scars
    • sometimes require intralesional steroids
  • Consideration of Accutane or spironolactone
  • Associated menstrual irregularity or hirsutism
    • polycystic ovarian syndrome
acne treatment plans27
ACNE Treatment Plans

Contemporary Peds Dec. 2000

acne treatment plans29
ACNE Treatment Plans

Contemporary Peds Dec 2000

acne treatment plans31
ACNE Treatment Plans

Contemporary Peds Dec 2000

acne references required reading
ACNEReferences (required reading)
  • Pediatric Clinics North America
    • August 2000
  • Contemporary Pediatrics
    • Dec 2000
  • Pediatric Annals
    • January 2000

Available in the Peds Office