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Table : Association between cognition (i.e. executive function) and quality of life

VUmc. Long Term Cognitive Outcome and Quality of Life in Meningioma Patients after Neurosurgery with or without Radiotherapy. Results Meningioma patients performed worse in 15 out of 20 tasks (p<0.01), and in 5 out of 6 cognitive domains (Figure A),

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Table : Association between cognition (i.e. executive function) and quality of life

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  1. VUmc Long Term Cognitive Outcome and Quality of Life in Meningioma Patients after Neurosurgery with or without Radiotherapy • Results • Meningioma patients performed worse in 15 out of 20 tasks (p<0.01), and in 5 out of 6 cognitive domains (Figure A), • 38 patients (43%) had major impairment (> 1.5 SD deviation from healthy controls) in executive functioning (p<0.001), • Not correlated with: Visual or motor deficits, tumor size, tumor volume, or adjuvant radiotherapy (Figure B), • Correlated with AED use (but not with seizure control) (Figure C) • Lower quality of life scores are associated with poorer cognitive functions, i.e. with impaired executive functioning (Table) Purpose:Evaluation of long term cognitive outcome and quality of life (QoL) at least one year after neuro-surgery (SU)  radiotherapy (RT). * * * *p<0.01 * * • Patients and Methods: • 89 WHO grade I meningioma patients* • >1 year after surgery alone (n=67) or • surgery plus adjuvant radiotherapy (n=22):conformal EBRT 54Gy in 30 fractions • 89 controls, matched for age, sex, education • Male : Female = 23 (26%) : 66 (74%) • Mean age: 58.6 years • Anti-epileptic drugs (AED): 23 (26%) • Seizure control: 57 (64%) • Cognitive test battery: 20 tests covering 6 cognitive domains, • Quality of life (SF 36): 36 items covering 8 QoL domains • Statistics: • Mean Z-score = measure for deviation • Students's t-test; multivariate stepwise linear regression. A Lukas J. A. Stalpers1, Martin Waagemans2, Miriam Wumkes1, David van Nieuwenhuizen2, Monica Dijkstra2, Sieger Leenstra3, Clemens Dirven4, Jaap C. Reijneveld1,2, Martin Klein2 1AMC-University of Amsterdam, 2VUmc-Free University Amsterdam, 3Sint Elisabeth Hospital, Tilburg, 4Erasmus University MC, Rotterdam, The Netherlands. Table: Association between cognition (i.e. executive function) and quality of life Deviation from healthy controls (SD of mean Z-score) • Conclusions: • Late cognitive dysfunctioning… • is common in meningioma patients (including ‘small and simple neurosurgical cases’ ), • is not associated with adjuvant radiotherapy, • is associated with anti- epileptic drugs, • has a negative impact on Quality of Life. B *p<0.05 * * C Cognitive Domain R2 = Proportion of explained variance *6 patients with grade III ‘atypic’ meningioma excluded Author Disclosure Block: All authors: No conflicting interests

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