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DANGER!. DANGER!. ARTIFICIAL & SYNTHETIC COLOURS AND FLAVOURS AT WORK. INTRODUCTION Artificial colours provide attractive colors to the product.

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DANGER!

DANGER!

ARTIFICIAL & SYNTHETIC COLOURS AND FLAVOURS AT WORK

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INTRODUCTIONArtificial colours provide attractive colors to the product.

MAJOR CLIENTS FOR CHEMICAL INDUSTRYFood and Pharmaceutical industry were the two major clients for the increased sales of the Artificial colours and flavours.

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CONTROVERSIAL ASPECTThe most controversial aspect of artificial colours and flavours is the consumption by the children and the subsequent effect of the same in relation to the behavioral and learning abilities in children.AWARENESSAwareness pertaining to dangerous consequences in early life and after prolonged use of artificial colours and flavours has increased.

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Hazards of artificial colours!HYPERACTIVITY:Defination : Hyperactivity is a diagnosable syndrome recognised by health professionals as Attention Deficit Hyperactivity Disorder(ADHD). It includes the following symptoms:Distractibility, poor tolerance to frustration, aggressiveness, anti social behavior excitability, aggression, difficulties with coordination, lability of mood, anxiety, impulsiveness, disabilities of both cognitive and learning functions.

Dickerson JWT: Diet and Hyperactivity. J Human Nutr, 34:167-174, 1980Miller M and Millstone E: Food Additives Campaign Team: Report on Colour Additives. FACT, June, 1987

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Hazards of artificial colours!

Hyperactive Infant Leads to …

Symptoms :

Restless, irregular sleep patterns, excessive crying or screaming, poor feeders.

Ref: Dickerson JWT: Diet and Hyperactivity. J Human Nutr, 34:167-174, 1980

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Hazards of artificial colours!

Hyperactive Toddlers which Leads to …

Symptoms :

Seldom walk but run, incapable of playing with any objects for more than few seconds, impulsive behaviour with complete lack of any apprehension and fear.

Ref: Dickerson JWT: Diet and Hyperactivity. J Human Nutr, 34:167-174, 1980

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Hazards of artificial colours!

School going Hyperactive Children

Symptoms :

Restless, inattentive, distractable and frequently display aggressive and anti-social tendencies, academic performances generally poor and lower school grades.

It can be a asypmtomatic also leading to Adulthood problems like Adult Alcoholism, Hysteria etc.*

Ref: Dickerson JWT: Diet and Hyperactivity. J Human Nutr, 34:167-174, 1980

* Ref.: Nelson book of paed. Book 1 pg. 91-92 Vol. 15.

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OTHER SIDE EFFECTS

OF ARTIFICIAL

COLOURS

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Hazards of artificial colours!

1. Artificial colours worsen behaviours characterized by irritability. (Mattes and Gittelman Klien experiment.)

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Hazards of artificial colours!

2.Erythrosine, Ponceau 4R, Allura Red, Sunset yellow, Tartrazine, Amaranth, Brilliant Blue, Blue, Fast Red E, Orange GGN’.These inhibit mitochondrial respiration which results in Oxidative stress and mitochondrial disease.

-Effect of organic synthetic food colours on mitochondrial respiration.Reyes FG, Valim MF, Vercesi AE. School of Food Engineering, State University of Campinas, Sao Paulo, Brazil.

-Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system

Clin J Physiol. 2001 Mar 31; 44(1):1-11. Wei YH, Lu CY, Ma YS, Lee HC.

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Hazards of artificial colours!

3. Azo dye (like tartrazine) has been proposed as one of the source of potential genotoxic agents.

Evidence for direct-acting oxidative genotoxicity by reduction products of azo dyes.Sweeney EA, Chipman JK, Forsythe SJ.Department of Life Sciences, Nottingham Trent University, England.

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Hazards of artificial colours!

4. Artificial colours cause skin rashes in Children.

-Study of skin rashes after antibiotic use in young children.Huang SW, Borum PR.Department of Pediatrics, University of Florida College of Medicine, Gainesville 32610, USA

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TARTRAZINE

Formula : C6H9N4Na3O9S2

Chemical name: Trisodium salt of 3-carboxy-5-hydroxy-1-p-sulfophenyl-4-p-sulfophenyl-azopyrazole.

Side effects:

Acute bronchospasm, non-immunologic urticaria, eosinophilia and angio-oedema.

Increases urinary Zinc secretions in hyperactive Children, Deficiency of B6 and Zinc.

Banned in Norway and Australia.

Used in Shelcal Superkid

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SUNSET YELLOW FCF

Formula : C16H15N2Na2O7S2

Chemical Name: Disodium salt of 1-p-sulfophenyl-azo-2-napthol-6-sulfonic acid.

Side Effects : Urticaria, rhinitis, nasal congestion,allergies, hyperactivity, kidney tumours, distaste for food, abdominal cramp.

Usage is banned in Norway.

Used in Colimex drops, Shelcal Superkid, Crocin, Metacin

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CARMOISINE

FORMULA: C10H12N2Na2O7S2

Chemical Name : Disodium salt of 2- (4-sulphol-1-napthylazo) -1-napthol-4-sulphonic acid.

Side Effects : Carcinogenic.

Banned in Sweden, USA, Austria, Norway

Used in Paralife, Crocin

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ERYTHROSINE

Formula: C20H6I4Na2O5H2O

Chemical Name: Disodium salt of 9-o-carbosyphenyl-6-hydroxy2,4,5,7-tetraiodo-3-isoxanthone.

Side Effects: Childhood hyperactivity

Banned in USA and NorwayUsed in Ostocalcium, Dexorange .

hazards of propylene glycol
HAZARDS OFPropylene Glycol:

Commonly used in Paracetamol Syrup

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Hazards of Propylene Glycol:

Serum Osmolality in low birth-weight, premature infants, lactic acidosis, haemolysis and CNS toxicity in Children.Ref: Martindale, 32nd edition, pg 1622.1

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Hazards of Propylene Glycol:

PROPYLENE GLYCOL (PG)

1000 mg of PG is needed for disolving 100 mg of Paracetamol

Concentration of PG exceeds far above that recommended by FAO/WHO expert committee.

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ALL PRODUCTS AT MEYER

Contain only

Natural Colours & Flavours

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1) Sensitivity is extremely rare.

2) No allergic side effects.

3) Evidence of test on natural colour and flavours conclude that there were no reports of adverse reactions.

(Role of natural color additives in food allergy, Lucas CD, Hallagan JB, Taylor SL. Adverse Food Nutrition Res. 2001;43: 195-216

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Conclusion:

  • Natural colours and flavours are superior to Artificial Colours and flavours because artificial colours are associated with:
  • 1. Hyperactivity in Children.
  • Mutagenic actions (as evident from clinical trials).
  • 3. Allergic symptoms like Skin rashes, Urticaria, diarrhoea, CNS toxicity, etc.
  • 4. Deficiency of essential micro-nutrients required for normal development of Child.
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Artificial colours and flavours should be avoided in the formulations because of their side effects.

As such Paediatric preparations must be completely devoid of any chemical that threatens to cause allergic reactions. Drug industry should stop using these additives to offer the society better & safer preparations for human health.

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Meyer – A pioneer in Pediatric products has the motto of safety, efficacy and complete healthcare through constant innovation. Infact, Meyer is the only company that takes into account the safety concern associated with the additives.

Hence all the paediatric product

of Meyer viz., Calcimax Supergems, Colic aid,

Mim drops, Kidicare+, Fevril suspension, Babygesic suspension are free from the side effects of hazardous artificial colours and flavours. This way Meyer assures the efficacy with safety to all its customers.

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There is always a requirement of additional calcium in the children during the phase of growth. It is at this time that the foundation of achievement of peak bone mass is laid down.

Calcimax Supergems

Provides calcium along with pro calcium cofactors

that helps the proper utilisation of Calcium.

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Colicaid is the pioneer in the safe treatment of infantile colic. Colicaidhad Simethicone that has anti-flatulent Action. Dill oil and fennel oil act as carminative.

Colicaid Is free from the side effects of Dicyclomine like dryness of mouth, apnoea, sedation and even death.

Colicaid has natural colours and flavours.

Therefore,

Colicaid is safest yet highly effective.

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FEVRILsuspension

The first Paediatric Product formulated against FEVERS and fever associated Symptoms,vomiting.

FEVRILprovides paracetamol without Propylene Glycol, a solvent used in other paracetamol preparations.

Hence FEVRIL offers relief to children from fever and associated symptoms effectively with greater safety.

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In infantile fever, the tastiest paracetamol suspenion that an infant can relish is Babygesic Suspension.

Babygesic Suspension is completely free from the side effects of Propylene glycol (CNS toxicity)

and allergic reactions of hazardous artificial colours and flavours.

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All School going Children need a balance of Physical and Intellectual development.

Kidicare+ Provides a complete balance of essential vitamins and nutrients that assures the proper intellectual and physical development of a school going children.

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All the infants needs essential vitamins and minerals for improved Immunity and moderate iron for proper development.

Mim drops fortified with essential

Vitamins and minerals that not only helps in Proper physical and mental growth but also improves immunity and provides protection against infections.