Molecular Mechanisms in Purine Synthesis and Glutamine Metabolism

Jan 27, 2026

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This article explores the intricate biochemical pathways involved in purine synthesis, focusing on key intermediates such as AICAR and the roles of enzymes like glutamine amidotransferase. It details the interactions and transformations occurring within these pathways, including the significance of glutamine and phosphoribulosyl-formimino-5-AICAR in cellular processes. Understanding these mechanisms is crucial for insights into metabolic regulation and the development of potential therapeutic strategies targeting purine metabolism.

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Molecular Mechanisms in Purine Synthesis and Glutamine Metabolism

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Mechanism
NH2 O N H N C P O CH2 N N OH CH2 R H O Glutamine OH O P Phosphoribulosyl-formimino-5-AICAR-P Glutamine amidotransferase P O CH2 N OH Glutamate C NH2 H N H OH N O Imidazole glycerol phosphate N H2N R AICAR O P
NH2 O N H N C P O CH2 AICAR N N OH CH2 R NH2 H O N O OH O P N Phosphoribulosyl-formimino-5-AICAR H2N R O + P O H N C P O CH2 H OH CH2 Purine Synthesis H Histidine OH O
O H O H N C P O CH2 - C CH2 CH2 C COO H H OH CH2 H2N H H3N + Glutamine OH O
OH H H N C N CH2 P O H OH CH2 H H O OH
H N C N CH2 P O H OH OH CH2 H H O OH
CH2 P O N OH C H N H OH OH CH H
CH2 P O N OH C H N H OH C Imidazole glycerol phosphate