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Metabolism of nucleic acids

Metabolism of nucleic acids. the structure & function. The structure of nucleic acids. 1. summarize. the discovery The function The headway. A. nucleotides. base （ purine、pyrimdine ）+ ribose （ deoxyribos N-glycosyl linkage nucleoside+phosphate

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Metabolism of nucleic acids

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  1. Metabolism of nucleic acids the structure & function

  2. The structure of nucleic acids 1.summarize the discovery The function The headway

  3. A. nucleotides

  4. base（purine、pyrimdine）+ribose（deoxyribos • N-glycosyl linkage • nucleoside+phosphate • phosphoester linkage • nucleotide • phosphodiester linkage • nucleic acid

  5. The structure of the • nucieic acid

  6. 一、the building block molecule of nucleic acid--nucleotide In RNA: AMP、CMP、GMP、TMP In DNA: dAMP、dCMP、dGMP 、dUMP

  7. The physiological function of the nucleotides

  8. 二、the linkage ---- phosphodiester bridge 3’terminal 5’terminal Nucleotide residues

  9. 三、the primary structure of nucleic acid definition writing method polinucleotide oligonucleotide

  10. 四、the structure of DNA 1.the primary structure of DNA * concept * writing method

  11. 5’-AATTCGGATCTTAGC-3’ * characteristics specificity in race non specificity in tissues Chargff Law

  12. 2.the secondary structure of DNA Watson-Crick double helix structure

  13. 3.the force maintaining the double helix stability *hydrogen bond * Stacking force

  14. 4. Some difference steric conformation types of DNA double helix

  15. A型 B型 Z型 结晶湿度 75% 92% 高盐溶液结晶 右手 左手 方向 右手 2nm 2.55nm 直径 2.46nm 3.4nm 螺距 表面只有一大沟碱基为嘌啉呤，嘧啶交替， 0.34nm 0.23nm 相邻碱基距离 螺旋一周所含 碱基 12 11 10

  16. 5. The tertiary structure of nucleic acid The length of genome DNA 6106Kb DNA supercoiling

  17. The basic structure of chromosome --- nucleosome

  18. Nucleosome （ DNA double helix of containing 200bp ） 140bp DNA double helix histone (H2A1)2,(H2B)2,(H3)2,(H4)2，octamer Core particles 60bp DNAdouble helix fragment+H1histone（linkage region） Core particles a string of beads of nucleosome further fold to form chromosome

  19. 五、the structure of RNA 1.summarize • Content • components & linkage • inhomogeneity • steric conformation • function

  20. 2. The structure of tRNA * kinds * commonness

  21. (1) The primary structure of tRNA * 5’ PG, 3’ CCA * more rare bases

  22. (2) The secondary structure of tRNA Characteristic structure

  23. *Amino acid arm • * DHU arm DHU ring • * T ψC arm TψC ring • Anticodon arm anticodon ring • extra fork

  24. (3) The tertiary structure of tRNA twisted L

  25. 3. The structure of mRNA • Summarize • * characteristic

  26. Prokaryotes --polycistronic Eukaryotes-- monocistronic

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