The Etiology of Depression (BLOA). Neurotransmitters. Catecholamine and Serotonin Hypothesis. Joseph Schildkraut came up with the Catecholamine Hyphothesis in 1965 suggesting that depression is associated with low levels of noradrenaline (or norepinephrine).
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Estrogen has a mixed effect on norepinephrine (more in women) and allows them to feel better and alert. But for some women, high norepinephrine might be the cause of the anxiety and panic attacks that estrogen seems to produce in some women.
Older men would be particularly vulnerable to these effects, because serotonin receptors are already decreased from normal aging
If you have a parent or sibling with depression, you may be 1.5 to 3 times more likely to develop the condition compared to those who aren’t closely related to someone who’s depressed