ADRENAL CORTEX AND CORTICOSTEROIDS. Zona glomerulosa. Regulation Angiotensin II, K+ Impt enz = P450 aldo Produces mineralocorticoids Functions: Stim’s Na+ reabs’n incr’d ECF vol, Decr’d plasma K+, Incr’d plasma pH . Zona fasciculata . Regulation ACTH Impt enz’s
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Cortisol:dominant glucocorticoid in humans, synthesized from progesterone in the zona fasciculata of the adrenal cortex, involved in stress adaptation, elevates blood pressure and Na+ uptake, numerous effects on the immune system
Aldosterone: the principal mineralocorticoid, produced from progesterone in the zona glomerulosa of adrenal cortex, raises blood pressure and fluid volume, increases Na+ uptake
Testosterone: an androgen, male sex hormone synthesized in the testes, responsible for secondary male sex characteristics, produced from progesterone
Estradiol: an estrogen, principal female sex hormone, produced in the ovary, responsible for secondary female sex characteristics