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1. How to Properly Clean and Maintain Your Cleanroom Floors Maintaining a cleanroom's integrity depends heavily on rigorous cleanliness protocols—especially when it comes to flooring. Floors incleanroom environmentsare high-traffic zones and prime areas for particle accumulation. Proper cleaning and maintenance of cleanroom floors help preserve compliance with ISO and GMP standards, extend the life of cleanroom surfaces, and prevent contamination of sensitive processes. Here’s a step-by-step guide to properly clean and maintain your cleanroom floors: 1. Understand Your Cleanroom Classification Before initiating a cleaning procedure, identify the cleanroom classification (e.g., ISO 3 to ISO 8). Each classification has specific cleanliness standards that dictate allowable particle counts and acceptable cleaning materials. Tailor your cleaning frequency and materials to meet these requirements. 2. Use Cleanroom-Approved Cleaning Equipment Utilize tools specifically designed for cleanroom environments:  Flat mop systems with knitted polyester or microfiber mop heads  Autoclavable buckets made of stainless steel or cleanroom-safe plastics  Non-shedding, low-lint wipes  HEPA-filtered vacuum cleaners for dry cleaning when necessary Ensure all equipment is pre-cleaned and sterilized before entering the cleanroom. 3. Choose the Right Cleaning Agents Only use non-residue, low-ionic, and non-reactive cleanroom-compatible disinfectants and detergents. Common choices include:  Isopropyl alcohol (IPA) for spot cleaning and disinfecting  Sterile water or DI water (deionized)  Quaternary ammonium compounds for microbial control Rotate disinfectants periodically to reduce microbial resistance. 4. Establish a Cleaning Protocol Follow a consistent, methodical approach:  Dry clean first if needed (e.g., vacuuming)  Wet mop floors in overlapping "S" patterns, moving from the cleanest area (usually near entrances) to the dirtiest  Replacemop headsregularly during the process to avoid cross-contamination  Use double-bucket systems to separate clean and dirty solutions

2. For high-traffic areas, consider cleaning multiple times a day. 5. Routine Maintenance and Monitoring In addition to daily cleaning:  Schedule periodic deep cleaning (weekly or monthly) using more thorough scrubbing or steam-cleaning equipment  Inspect floors for damage, cracks, or wear that could trap particles  Keep detailed logs of cleaning schedules, agents used, and personnel involved  Conduct surface particle count testing as part of environmental monitoring 6. Train Personnel Ensure all cleanroom staff and janitorial teams are trained in:  Proper gowning procedures to avoid introducing contaminants  Cleanroom floor cleaning techniques and protocols  Emergency spill containment and cleaning processes 7. Consider Floor Mats and Protective Coverings Use cleanroom entrance mats to reduce dirt transfer from foot traffic and temporary floor coverings during maintenance work to protect surfaces.