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Nucleotide Degradation

Nucleotide Degradation. Nucleotide Degradation. 50X dATP. SCID. Gout is caused by an excess of uric acid. DNA and RNA in diet. Xanthine. Xanthine oxidase. Allopurinol. Uric acid. Elion and Hichings 1988 Nobel Prize ‘Rational design of drugs’. Purine Salvage Pathways.

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Nucleotide Degradation

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  1. Nucleotide Degradation

  2. Nucleotide Degradation 50X dATP SCID

  3. Gout is caused by an excess of uric acid DNA and RNA in diet Xanthine Xanthine oxidase Allopurinol Uric acid Elion and Hichings 1988 Nobel Prize ‘Rational design of drugs’

  4. Purine Salvage Pathways phosphoribosyltransferase AMP + PPi Adenine + PRPP GMP + PPi Guanine + PRPP Lesch-Nyhan Syndrome -increasing levels of PRPP in patients (male children) suffering from Lesch-Nyhan Syndrome leads to increased de novo purine biosynthetic pathways -gout -brain dependent upon salvage pathways

  5. Nucleotide Metabolism and Chemotherapy Glutamine Amidotransferase Inhibitors Folate Analogs

  6. Inhibitors of dTMP synthesis

  7. Inhibitors of dTMP synthesis

  8. Thymidylate synthase mechanism:

  9. FdUMP is a suicide inhibitor of thymidylate synthase 1,3 hydride shift is blocked by the presence of Fluorine

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