Nucleotide Bases - PowerPoint PPT Presentation

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Nucleotide Bases

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  1. Nucleotide Bases Each base has a slightly different shape Refer to by first letter of name (A,T,G,C) Chargaff’s Rules 1950’s – Biochemist Erwin Chargaff Found: Amount of Adenine always = Amount of Thymine Amount of Guanine always = Amount of Cytosine

  2. DNA Structure Double Helix 2 sides of “ladder” = alternating sugar and phosphate The rungs of the ladder = pair of nucleotide bases A pairs with T G pairs with C How does this structure explain Chargoff’s findings?

  3. Making Copies of DNA A pairs with T and G pairs with C therefore One side of DNA is complementary to the other. EX. A sequence ACCG always binds to TGGC. Allows for DNA to replicate.