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Nucleotide Bases. Each base has a slightly different shape Refer to by first letter of name (A,T,G,C) Chargaff’s Rules 1950’s – Biochemist Erwin Chargaff Found: Amount of Adenine always = Amount of Thymine Amount of Guanine always = Amount of Cytosine. DNA Structure. Double Helix

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nucleotide bases
Nucleotide Bases

Each base has a slightly different shape

Refer to by first letter of name (A,T,G,C)

Chargaff’s Rules

1950’s – Biochemist Erwin Chargaff Found:

Amount of Adenine always = Amount of Thymine

Amount of Guanine always = Amount of Cytosine

dna structure
DNA Structure

Double Helix

2 sides of “ladder” = alternating sugar and phosphate

The rungs of the ladder = pair of nucleotide bases

A pairs with T

G pairs with C

How does this structure explain Chargoff’s findings?

making copies of dna
Making Copies of DNA

A pairs with T and G pairs with C therefore

One side of DNA is complementary to the other.

EX. A sequence ACCG always binds to TGGC.

Allows for DNA to replicate.