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Review: Cells of the Immune System

Review: Cells of the Immune System. From Larsson and Karlsson (2005). Review: Cells of the Immune System. Larsson and Karlsson (2005). Review: Myeloid cells. Dendritic cell. Review: Myeloid cells.

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Review: Cells of the Immune System

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  1. Review: Cells of the Immune System From Larsson and Karlsson (2005)

  2. Review: Cells of the Immune System Larsson and Karlsson (2005)

  3. Review: Myeloid cells Dendritic cell

  4. Review: Myeloid cells •Macrophages – phagocytes, antigen presenting cells (APCs), specialized cells different organs, secrete cytokines, produce complement proteins, can produce ROS/RNS. •Neutrophils – phagoctyes, can produce ROS/RNS, secrete antimicrobial peptides, 1st cell type to migrate from blood to infections, main targets are bacteria and fungi •Basophils – secrete cytokines, involved in allergic response •Eosinophils– phagocyte, targets parasites

  5. Review: Lymphocytes Lymphocytes: T cells B cells Natural killer cells

  6. Review: Lymphocytes • B cells – naïve B cells: contain antigen binding receptor (or membrane bound antibody), once activated – memory cells: provides memory of antigen/antibody interaction; plasma cells: secrete soluble antibody • T cells - contain antigen binding receptor (TCR) T H cells: secretes cytokines that activate B cells, T C cells, macrophages and others. T Ccells: eliminates altered/damaged self cells (particularly those infected by viruses), fights tumors cells, secrete cytotoxins. T regcells: helps suppress immune response, plays a role in tolerance .

  7. Review: Cells of the Immune System Lymphoid cells •Natural killer cells – distinct from T and B cells due to lack of an antigen binding receptor, similar in function to T Ccells, macrophage activation, defense against viruses, fight tumor formation, secrete cytotoxins. Derived from both lymphoid and myeloid precursors •Dendritic cells – phagoctyes, antigen presenting cells (APCs), can produce ROS, secrete proinflammatory cytokines, secrete antimicrobial peptides.

  8. Review: Organs of the Immune System Primaryand secondary lymphoid organs:

  9. Review: Innate and adaptive immunity

  10. Review: Innate Immune Response

  11. Review: Adaptive Immune Response Antigen/Antibody interactions: Antigen – any substance that binds specifically to an antibody or a T cell receptor (TCR). Antibody- a protein (immunoglobulin) that recognizes a specific region (component) of an antigen. Properties of immunogenicity: Foreignness Molecular size Chemical composition/complexity Processing/presentation Host factors Dosage Route of entry

  12. Antibody-Mediated Effector Functions Opsonization Assist and activate complement system ADCC

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