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Naturally Programmed Cell Death, Apoptosis, and Cancer. Folder Title: Apoptose. or . April 12, 2005. TtlApop. What happened to your webbed feet? You guys are dethpicable. DaffyDuc. God and Michelangelo. Creation by Subtraction. Evolution: Selective Reproduction

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naturally programmed cell death apoptosis and cancer

Naturally Programmed Cell Death, Apoptosis, and Cancer

Folder Title: Apoptose

or ...

April 12, 2005

TtlApop

slide2

What happened to your webbed feet?

You guys are dethpicable.

DaffyDuc

god and michelangelo
God and Michelangelo

Creation by Subtraction

Evolution:

Selective Reproduction

Selective Death

Subtract

selective cell death in normal development and normal organismic functioning
Selective Cell Death in Normal Development and Normal Organismic Functioning

Developmental Remodelling

  • Tadpole to Frog
  • Human Fetal Remodelling
  • Immunological Self-Tolerance

Normal Physiology

  • Post-Lactation Breast Involution
  • Menstruation
  • Normal Immune T-Cell Killing

NormApop

necrosis vs apoptosis
Necrosis vs Apoptosis

Apoptosis

Condensed Nuclear Fragments

Shrunken Cytoplasm

Membrane Blebs (Apoptotic Bodies)

Phagocytosis without Inflammation

Necrosis

Clumped Chromatin

Swelling of Organelles

Cell Distension

Membrane Disruption

Inflammation

Kill&Die

slide8

Membrane Blebs

on a Cell

Undergoing

Apoptosis

from Scientific American,

December, 1996

ApoBlebs

slide9

DNA Lysis into

"DNA Ladder".

DNA from Apoptotic

Cell.

From Ruddon, 3rd Ed.,

Figure 10-8

ApoDNA

genetic control of genetically programmed cell death
Genetic Control of "Genetically Programmed Cell Death"

Apoptosis Gene

Effect on Apoptosis

Blocks

Stimulates

Wild-type Stimulates

Mutant Blocks

Stimulates

Cellular Location of Protein Product

Mitochondrial Membrane

Nuclear Envelope

Endoplasmic Reticulum

Nucleus

Nucleus

Cell Membrane

bcl-2

myc

p53

p53*

APO-1/

FAS

ApoGenes

exogenous genetic suppressors of apoptosis
Exogenous Genetic Suppressors of Apoptosis

Adenovirus E1b Oncoprotein

Ras

v-abl

compox crm a gene product

ExoApop1

exogenous inducers of apoptosis
Exogenous Inducers of Apoptosis

Cytotoxic T-Lymphocyte Attack on Target Cells

Loss of Growth Factors

Loss of Responses from Neighboring Cells

DNA-Directed Anti-Neoplastic Agents

ExoApop2

more exogenous inducers of apoptosis from ruddon 3rd ed p 397
More Exogenous Inducers of Apoptosis(from Ruddon, 3rd Ed., p. 397)

Differentiation Signals

Removal of Growth Factors or Required Hormones

Exposure to Transforming Growth Factor B (TGF-B)

Tumor Necrosis Factor (TNF)

Glucocorticoids (Immune-modulating Corticosteroids)

DNA-damaging Antineoplastic Agents

Environmental Toxins

Agents Stimulating Ca Influx (Calcium Ionophores)

Cytoskeletal-directed Microtubule Disruptors

Microfilament-directed Cytochalasin B Inhibits formation of Apoptotic Bodies, but not apoptosis itself

ExoApop3

slide16

Normal T-Cell Activation by

Antigen-Presenting Cells.(from Sci. Am., Dec, 1996)

TCellAct

slide17

Activated T-Cell Down-regulation via FAS Cell-Surface

Protein and Ligand Binding to FAS. (from Sci. Am., Dec., 1996)

TCelDown