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The Regulation of Cell Death: APOPTOSIS - PowerPoint PPT Presentation


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The Regulation of Cell Death: APOPTOSIS. Presented by: Jesse Kemp. Introduction and Overview. Death Due to External Source or Injury vs. Death by Committing Suicide Why Is There a Need For This Type of Pathway? Causes of Apoptosis Mechanism of Apoptosis.

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Presentation Transcript
introduction and overview
Introduction and Overview
  • Death Due to External Source or Injury vs.

Death by Committing Suicide

  • Why Is There a Need For This Type of Pathway?
  • Causes of Apoptosis
  • Mechanism of Apoptosis
death by external source or injury
Death by External Source or Injury
  • Toxin Damage
  • Mechanical Damage
  • Uncontrolled Swelling
  • Leakage of Cell Contents
  • Resulting Inflammation of Surrounding Tissue
death by committing suicide
Death by Committing Suicide

While committing suicide cells:

  • Shrink
  • Chromatin Degraded
  • Mitochondria Break Down
  • Break into Membrane-bound Fragments
  • Phosphatidylserine Exposed
  • Phagocytic Receptors
  • Inflammation Inhibition
purpose for this pathway
Purpose for this Pathway!

Apoptosis is needed for:

  • Proper Development of the Organism

ex) Formation of Fingers and Toes

ex) Resorption of the Tadpole Tail during Metamorphosis

  • Destruction of Cells that Pose a Potential Threat to the Organism

ex) Cells Infected with Viruses

ex) Cells of the Immune System

ex) Cancerous Cells

balancing act
Balancing Act

Within Every Organism, there is a Continual Battle Fought Between the Withdraw of Positive Signals and the Receipt of Negative Signals

  • Positive Signals
  • Negative Signals
mechanism of apoptosis
Mechanism of Apoptosis
  • 3 Different Pathways

Internal (Mitochondrial) Pathway

External (Death Receptor) Pathway

Non-Caspase Pathway

alternate pathways
External Pathway (Death Receptor)

Fas and TNF Receptor

Death Activator (FasL)

Caspase 8

Phagocytosis

Ex) Cytotoxic T Cells

Non-Caspase Pathway

AIF

Released from Mitochondria

Migration to the Nucleus

DNA Binding

Alternate Pathways
conclusion
Conclusion
  • Sources of Cell Death
  • Need for the Apoptosis Pathways
  • Causes of Apoptosis
  • Mechanisms of Apoptosis