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Impact of Splenectomy on CKD-Related Sepsis Severity in Mice

Study evaluates how splenectomy affects sepsis severity in CKD via various biomarkers measured post-surgery, aiding in understanding potential treatment strategies.

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Impact of Splenectomy on CKD-Related Sepsis Severity in Mice

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  1. Supplemental Figure 3. Splenectomy reduces CKD-sepsis severity CD-1 mice were subjected to 5/6 Nx, and after 4 weeks subjected to splenectomy (day 0, black, dark gray bars). Three days after splenectomy (d3) sham surgery (white, black bars) or CLP (light, dark gray bars) was performed, then Scr (A), BUN (B), ALT (C), AST (D), TNFa (E), IL-6 (F), and IL-10 (G) were measured at 18 h. *P<0.05 vs 5/6 Nx-CLP

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