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Boys Town National Research Hospital (BTNRH) Genetic & Molecular Biology Labs. Auditory Neurobiology. Lymphatic Research. Neurochemistry. Cell Signaling & Angiogenesis. Retinal Neurobiology. Gene Expression. Vestibular Neurogenetics. Gene Marker & Identification.
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Boys Town National Research Hospital (BTNRH)Genetic & Molecular Biology Labs
Cell Signaling & Angiogenesis
Gene Marker & Identification
Goal is to understand the basic mechanisms underlying auditory system development in normal and pathological systems.
Goal is to identify the molecular and biochemical mechanisms by which endogenous angiogenesis inhibitors prevent tumor development and growth
Sudhakar et al. (2005)
Study of molecular mechanisms underlying progressive pathologies resulting from mutations in basement membrane proteins; the role(s) of cell adhesion and integrin signaling proteins, cytokines and chemokines
Identification of genes associated with hearing loss and localization to the human gene map
Study of the lymphatic system as it relates to human inflammatory and malignant disease. Study of the molecules and mechanisms that contribute to lymphatic growth assessed by lymphangiogenesis
Lymphatic vessels drain extracellular fluid and improve the capacity for pathogen surveillance by directing fluid towards regional lymph nodes
(e.g., Mycoplasma pulmonis infection)
The role of neurotransmitters and receptors in the establishment of neural pathways and the formation of maintenance of synaptic connections.
Molecular mechanisms of hereditary retinal degeneration, particularly retinitis pigmentosa
Rod marker, rhodopsin (red), Cone marker, cone transducin γ (green)
Study of the molecular and cellular mechanisms of otoconia development in the vestibular system
Otoconia are composite crystals that overlie and provide optimal stimulus input to the sensory epithelium of the balance system. The crystals are critical for spatial orientation and balance.
Deletion of Oc90 gene leads to abnormal otoconia formation and balance deficits