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Plasma miR-221 Concentrations in Pancreatic Cancer Patients: Characterization and Analysis

This research investigates the concentrations of plasma miR-221 in 47 consecutive pancreatic cancer patients, comparing it with levels in benign tumors and normal controls. Using the Mann-Whitney U-test, significant differences were identified (p < 0.05). Supplementary data include figures and tables detailing the differential expression patterns and relationships between miR-221 in plasma and pancreatic cancer tissues. The study aims to provide insights into the potential of miR-221 as a biomarker for pancreatic cancer diagnosis and prognosis.

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Plasma miR-221 Concentrations in Pancreatic Cancer Patients: Characterization and Analysis

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  1. 25 miR-221 Ct value miR-375 20 15 10 5 Log concentration Supplementary Figure S1

  2. T-Bil AMY miR-221 concentration (amol/μl) miR-221 concentration (amol/μl) CA19-9 miR-221 concentration (amol/μl) Supplementary Figure S2

  3. Characteristics and plasma miR-221 concentrations of 47 consecutive PCa patients NOTE. Significant values are in boldface type. a P values are fromthe Mann-Whitney U-test and were considered significant at 0.05. Supplementary Table S1

  4. Differential expression pattern of plasma miR-221 in patients with pancreatic, pancreatic benign tumors, and normal controls a Five IPMNs, 2 serous cystadenomas, and 2 pancteatitis tumors were included in benign tumors. b 95% confidential interval c Plasma concentrations of each group were compared with those of normal controls by Mann-Whitney U test. Supplementary Table S2

  5. Relationship between miRNA-221 in plasma and pancreatic cancer tissues a Cut-off value of plasma miR-221 concentrations in healthy volunteers (mean+2SD): 4.047E-02 amol/μl b Cut-off value of miR-221/U6B ratios in normal pancreatic tissues (median): 1.00 Supplementary Table S3

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