1 / 4

PDG-PET/CT vs MRI: diagnostic value for spondylodiscitis

1 of 2. PDG-PET/CT vs MRI: diagnostic value for spondylodiscitis.

Download Presentation

PDG-PET/CT vs MRI: diagnostic value for spondylodiscitis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. 1 of 2 PDG-PET/CT vs MRI: diagnostic value for spondylodiscitis Retrospective study (2006-2013): N=70 pts with a clinical suspicion of spondylodiscitis or an infection or fever of unknown origin, undergoing 18F-fluorodeoxyglucose (FDG) PET/CT + contrast-enhanced MRI of the spine within ≤ 2 wk Exclusion criteria: MRI or FDG-PET/CT ≤6 wk after spinal surgery; known final fracture; no final clinical diagnosis Final clinical diagnosis of spondylodiscitis: 50/70 pts (71%): Based on positive cultures of blood and/or tissue + imaging suggestive of spondylodiscitis: 94% Based on imaging suggestive of spondylodiscitis + response to antibiotic Tx: 6% Smids C. ECCMID 2014 abs. eP227 Data from poster

  2. 2of 2 PDG-PET/CT vs MRI: diagnostic value for spondylodiscitis Compared with MRI, FDG-PET/CT has a superior diagnostic value for detecting early (<2 wk) spondylodiscitis and a higher sensitivity for detecting paravertebral and psoas abscesses Smids C. ECCMID 2014 abs. eP227 Data from poster

  3. 1 of 2 Antibiotic treatment (Tx) for vertebral osteomyelitis (VO) Multi-centre, non-inferiority RCT: N=351 pts with VO (mean age: 61 yr; 69% male): 6 weeks antibiotic Tx vs 12 weeks antibiotic Tx Most frequently prescribed antibiotics: For S. aureus: rifampicin (87.6%), fluoroquinolones (83.4%), methicillin (75.9%), aminoglycosides (74.5%) For Streptococcus spp: aminopenicillin (92.1%) For IE: aminoglycosides (80.4%), aminopenicillin (50%) Combination therapy: fluoroquinolones + rifampicin (79.1%) Dinh A. ECCMID 2014 abs. O258

  4. 2 of 2 Antibiotic treatment (Tx) for vertebral osteomyelitis (VO) • Median duration of iv antibiotic Tx: 20.8 days • Intolerance to antibiotic Tx: N=29 • Vancomycin: responsible for 21.1% of adverse events 6 weeks antibiotic Tx for VO seems to be non-inferior to 12 weeks Tx Dinh A. ECCMID 2014 abs. O258

More Related