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Collateral Damage From HLA Mismatching

Explore the collateral damage and rejection treatments during the first year of deceased donor kidney transplants due to HLA mismatching. Discover significant findings on rejection rates, steroid doses, Non-Hodgkin Lymphoma risks, osteoporosis, hip fractures, graft survival, causes of death, and the impact of HLA mismatches.

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Collateral Damage From HLA Mismatching

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  1. CollateralDamageFrom HLA Mismatching Gerhard Opelz

  2. Rejection Treatment During 1stYearDeceasedDonorKidneyTransplants 1990-2012 +84%

  3. Rejection Treatment During 1st Year A+B Mismatches 0 DR MM DR Mismatches 0 A+B MM +97% +57%

  4. Steroid Dose at Year 1 (mg/kg/d) A+B Mismatches 0 DR MM DR Mismatches 0 A+B MM

  5. *) > 90-Percentile Transplantation 89: 567-572, 2010

  6. Transplantation 89: 567-572, 2010

  7. Non-Hodgkin LymphomaDeceasedDonorKidneyTransplants HLA-A HLA-B HLA-DR Transplantation 89: 567-572, 2010

  8. Non-Hodgkin Lymphoma – EBV StatusKidneyTransplants 1995-2012 Transplantation 88: 962-67, 2009

  9. Pediatric Recipients Transplantation 90: 292-297, 2010

  10. Osteoporosisat Year 5 +50% Transplantation 91: 65-69, 2011

  11. Hip Fracture +170% Transplantation 91: 65-69, 2011

  12. Death With a Functioning GraftDeceasedDonorKidneyTransplants n=177,584 2% per year 5%

  13. Death With a Functioning Graft Am J Transplant 12: 3031-3038, 2012

  14. Causeof Death Infection Cardiovascular Cancer Am J Transplant 12: 3031-3038, 2012

  15. Death With a Functioning Graft Am J Transplant 12: 3031-3038, 2012

  16. Heart Transplants1990-2011

  17. Heart Transplants1990-2011

  18. LiverTransplants1990-2011

  19. Rejection Treatment First YearLiverTransplants 1990-2011

  20. Death Due toInfectionLiverTransplants 1990-2011

  21. SecondaryEffectsof HLA Mismatches

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