Organelle Case Study. Diseases that affect specific organelles. Task 1: Prior Knowledge and Research. Read about each of the following diseases that affect the organelles Take notes! Put on your doctor hat, delve into your investigative skills, and diagnose the patients. Dr. Ben Carson, MD.
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Diseases that affect specific organelles
Dr. Ben Carson, MD.
Author of “Gifted Hands” and “Think Big”. Look him up! Truly an inspiration!
Mary is a fifty-five year old female, who arrived in the ER at 4:35 p.m. with complaints of severe fever and pain. The attending physician took blood work and revealed that there was a high concentration of oxidative enzymes in the blood such as catalase, D-amino acid oxidase, and uric acid oxidase. In addition, there were relatively high levels of fatty acids in the blood, which the physician suggested they were not being properly metabolized. A density gradient procedure found that an organelle approximately 0.5 microns in diameter was missing. The physician also diagnosed Mary with having gout in the joints in her hands and feet, a condition which is caused by the accumulation of uric acid. That same night around 11:00 p.m., Mary began to lose feeling in her lower back. The doctors performed a routine spinal tap (ST) to see if there was an infection in her cerebral spinal fluid. This test turned out to be negative; however, the attending physician did take a biopsy which revealed the nerve cells in Mary’s back were not producing enough myelin, a dielectric material needed for proper nervous system signaling.
Lauren is a senior at a nearby high school. She is a good student who does her work on weekdays and likes to party on the weekends with her friends. A few months ago, Lauren developed a persistent cough that has worsened over time. She has also had trouble breathing over the past week or so. Her parents decided it was time she see a doctor and made an appointment with the family physician. Lauren arrived at the doctor's office the following day. The doctor asked her a number of questions about her health history and daily habits, including, whether or not she smoked cigarettes. Lauren responded that she started smoking cigarettes (about 2 per day) her freshman year of high school and does not intend to quit anytime soon. The doctor decided it was necessary to take a biopsy of the cells that line the bronchus (passageway to the lungs). After several days, the biopsy report has come back along with a micrograph of the bronchial cells. Lauren's cigarette smoking has badly damaged these organelles which are responsible for mucous and dirt moving up-and-out of her respiratory system. Analyze the micrograph (see "Case Study #2" image below) and determine what cell organelles have been damaged.
Olivia is a sixteen year old track star at a local school nearby. She arrived in the ER at 5:03 p.m. with complaints of extreme muscle weakness and loss of muscle coordination, particularly in her arms and legs! She told the attending physician that for the past few days, she had been pretty exhausted with little energy to do anything. Blood taken did show one particular abnormality. Her glucose levels were rather high although she was an athlete and did mention she ate carbohydrates the night before a race. However, this notion could be dismissed since she did not have a race in the past week. The doctors concurred that something else must be going on to render such high glucose levels (i.e. something was not breaking down these sugar molecules). In addition, the doctors ordered for a muscle biopsy to be performed. After viewing the tissue sample under the microscope, the doctors saw that the muscle fibers were ragged red which contained mild accumulations of glycogen and decreased activity for the enzyme cytochrome c oxidase
Analyze each patient. Tell which disease they have. Tell which organelle it affects. Support your findings from the information on the diseases researched.Write in complete sentences (paragraph format).Upload to Edmodo.
Be prepared to discuss your answers on 2.25.14
This counts as 0.5 Project/Test Grade!!