1 / 26

Regulation of Erythropoiesis

Regulation of Erythropoiesis. Dr Ghulam Mustafa. Regulation of Erythropoiesis. Importance Factors affecting Erythropoiesis Tissue Oxygenation Anemia, High Altitudes, Cardiac failure, Resp Problem ERYTHROPOITEN Vitamins Metals Proteins Hormones Other factors/Conditions.

betty_james
Download Presentation

Regulation of Erythropoiesis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Regulation of Erythropoiesis Dr Ghulam Mustafa

  2. Regulation of Erythropoiesis • Importance • Factors affecting Erythropoiesis • Tissue Oxygenation • Anemia, High Altitudes, Cardiac failure, Resp Problem • ERYTHROPOITEN • Vitamins • Metals • Proteins • Hormones • Other factors/Conditions

  3. Normal RBC Count • Importance: • Must Not fall • To supply oxygen from lungs to tissues • Must Not rise • Blood viscosity may increase • May impede blood flow

  4. Factors affecting Erythropoiesis • Tissue Oxygenation • Vitamins • Metals • Proteins • Hormones

  5. 1. Tissue Oxygenation – Most Important Regulator of Erythropoiesis • ANY CONDITION Decrease Tissue Oxygenation Increase Erythropoiesis • Anemia Immediately Increase RBCs production • Bone marrow destruction: Hyperplasia of remaining cells Increase production of RBCs

  6. High altitudes: • Partial pressure of oxygen in air less • Decrease in oxygen transport to tissues • Tissue hypoxia • Result? • Cardiac Failure • Inefficient pumping by heart • Decreased blood flow to peripheral vessels • Tissue hypoxia • Result?

  7. Lung diseases: • Failure of oxygen absorption in Lungs • Blood carries less Oxygen • Tissue hypoxia • Result? • All conditions have one common problem • HYPOXIA ERYTHROPOIETIN

  8. Erythropoietin • Glycoprotein • Mol weight 34000 • Sites of production • Kidneys • Liver • Brain, Uterus • If Erythropoiten production reduced • Effect of Hypoxia?

  9. Stimulants of Erythropoiten production: • RENAL MECHANISM • Anemic blood to kidney • Less oxygen supplied • Renal tubular cells - High O2 consuming • Stimulates production of Erythropoiten • NON RENAL MECHANISM • Hypoxia in other parts – Non renal sensor • Nor epinephrine, epinephrine, prostaglandins • In Renal failure?

  10. Formation of Erythropoiten • Erythrogenin – Renal Erythropoitic factor • Erythropoitinogen • Alpha globulin • Substrate for Erythropoiten • Stimulants of Erythrogenin • Hypoxia • cAMP • NAD • Hemosylates

  11. Role of EP in Erythropoiesis • Formed in response to Hypoxia within minutes • RBC production in 5 days • Erythropoiten • Stimulates Proerythroblasts formation • Causes cells to pass through various stages of Erythropoiesis rapidly

  12. Recombinant Erythropoiten • Anemia – Renal Failure • Blood doping • Erythropoiten - Athletes • Running – Increase Oxygen demand • Breathlessness • ERYTHROPOITEN – Increase RBC’s • Less dyspnea • DNA Recombinant Technique

  13. 2. Vitamins • Vit B12 & Folic acid • Essential for formation of thymidine triphosphate • Essential building block of DNA • Diminished DNA • Failure of nuclear maturation • Inadequate Erythropoiesis

  14. Vitamin C • Potentiate the effect of Folic acid • Also helpful in Iron • Absorption • Reducing Ferric to ferrous form • Pyridoxine: • Coenzyme for condensation of Glycine and succinyl-CoA • Riboflavin and Pantothenic acid • Heme formation • Cell growth and division

  15. 2. Minerals • Iron • Copper • Ceruloplasmin • Necessary for Iron transfer from storage sites • Bone marrow, Liver and Spleen • Cobalt • Forms a part of Vitamin B12 • Nickel and Manganese

  16. 3. Proteins • Adequate protein diet essential • Formation of Globin • Protein deficiency • Kwashiorkor • Prisoners • Protein losing Enteropathies • Renal disease- Proteinuria

  17. 4. Hormones • Testosterone • Growth hormone • Thyroid hormone • Cortisol • Adrenocorticotrophic hormone ACTH

  18. 5. Other Conditions Stimulating Erythropoiesis • Exercise • Excitement • Menstruation • Pregnancy • Menopause • More RBC Count in fetal life • HbF – Binds more oxygen

  19. Revision

  20. Regulation of Erythropoiesis • Importance • Factors affecting Erythropoiesis 1 Tissue Oxygenation • Anemia, High Altitudes, Cardiac failure, Resp Problem • ERYTHROPOITEN • Site of production • Stimulants for production • Mechanism of production • Role in Erythropoiesis

  21. 2 Vitamins • Vit B12 and Folic acid • Pyridoxine • Vitamin C • Riboflavin and Pantothenic acid 3 Metals • Iron, Cu, Co, Ni, Mn 4 Proteins 5 Hormones • GH, TH, CORTISOL, TESTOSTERONE, ACTH 5 Other conditions affecting…..

  22. If  you complain about your transport system, What about them?

  23. Thank you

More Related