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Regulation of Erythropoiesis PowerPoint Presentation
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Regulation of Erythropoiesis

Regulation of Erythropoiesis

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Regulation of Erythropoiesis

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  1. Regulation of Erythropoiesis Dr Ghulam Mustafa

  2. Regulation of Erythropoiesis • Importance • Factors affecting Erythropoiesis • Tissue Oxygenation • Anemia, High Altitudes, Cardiac failure, Resp Problem • ERYTHROPOITEN • Vitamins • Metals • Proteins • Hormones • Other factors/Conditions

  3. Normal RBC Count • Importance: • Must Not fall • To supply oxygen from lungs to tissues • Must Not rise • Blood viscosity may increase • May impede blood flow

  4. Factors affecting Erythropoiesis • Tissue Oxygenation • Vitamins • Metals • Proteins • Hormones

  5. 1. Tissue Oxygenation – Most Important Regulator of Erythropoiesis • ANY CONDITION Decrease Tissue Oxygenation Increase Erythropoiesis • Anemia Immediately Increase RBCs production • Bone marrow destruction: Hyperplasia of remaining cells Increase production of RBCs

  6. High altitudes: • Partial pressure of oxygen in air less • Decrease in oxygen transport to tissues • Tissue hypoxia • Result? • Cardiac Failure • Inefficient pumping by heart • Decreased blood flow to peripheral vessels • Tissue hypoxia • Result?

  7. Lung diseases: • Failure of oxygen absorption in Lungs • Blood carries less Oxygen • Tissue hypoxia • Result? • All conditions have one common problem • HYPOXIA ERYTHROPOIETIN

  8. Erythropoietin • Glycoprotein • Mol weight 34000 • Sites of production • Kidneys • Liver • Brain, Uterus • If Erythropoiten production reduced • Effect of Hypoxia?

  9. Stimulants of Erythropoiten production: • RENAL MECHANISM • Anemic blood to kidney • Less oxygen supplied • Renal tubular cells - High O2 consuming • Stimulates production of Erythropoiten • NON RENAL MECHANISM • Hypoxia in other parts – Non renal sensor • Nor epinephrine, epinephrine, prostaglandins • In Renal failure?

  10. Formation of Erythropoiten • Erythrogenin – Renal Erythropoitic factor • Erythropoitinogen • Alpha globulin • Substrate for Erythropoiten • Stimulants of Erythrogenin • Hypoxia • cAMP • NAD • Hemosylates

  11. Role of EP in Erythropoiesis • Formed in response to Hypoxia within minutes • RBC production in 5 days • Erythropoiten • Stimulates Proerythroblasts formation • Causes cells to pass through various stages of Erythropoiesis rapidly

  12. Recombinant Erythropoiten • Anemia – Renal Failure • Blood doping • Erythropoiten - Athletes • Running – Increase Oxygen demand • Breathlessness • ERYTHROPOITEN – Increase RBC’s • Less dyspnea • DNA Recombinant Technique

  13. 2. Vitamins • Vit B12 & Folic acid • Essential for formation of thymidine triphosphate • Essential building block of DNA • Diminished DNA • Failure of nuclear maturation • Inadequate Erythropoiesis

  14. Vitamin C • Potentiate the effect of Folic acid • Also helpful in Iron • Absorption • Reducing Ferric to ferrous form • Pyridoxine: • Coenzyme for condensation of Glycine and succinyl-CoA • Riboflavin and Pantothenic acid • Heme formation • Cell growth and division

  15. 2. Minerals • Iron • Copper • Ceruloplasmin • Necessary for Iron transfer from storage sites • Bone marrow, Liver and Spleen • Cobalt • Forms a part of Vitamin B12 • Nickel and Manganese

  16. 3. Proteins • Adequate protein diet essential • Formation of Globin • Protein deficiency • Kwashiorkor • Prisoners • Protein losing Enteropathies • Renal disease- Proteinuria

  17. 4. Hormones • Testosterone • Growth hormone • Thyroid hormone • Cortisol • Adrenocorticotrophic hormone ACTH

  18. 5. Other Conditions Stimulating Erythropoiesis • Exercise • Excitement • Menstruation • Pregnancy • Menopause • More RBC Count in fetal life • HbF – Binds more oxygen

  19. Revision

  20. Regulation of Erythropoiesis • Importance • Factors affecting Erythropoiesis 1 Tissue Oxygenation • Anemia, High Altitudes, Cardiac failure, Resp Problem • ERYTHROPOITEN • Site of production • Stimulants for production • Mechanism of production • Role in Erythropoiesis

  21. 2 Vitamins • Vit B12 and Folic acid • Pyridoxine • Vitamin C • Riboflavin and Pantothenic acid 3 Metals • Iron, Cu, Co, Ni, Mn 4 Proteins 5 Hormones • GH, TH, CORTISOL, TESTOSTERONE, ACTH 5 Other conditions affecting…..

  22. If  you complain about your transport system, What about them?

  23. Thank you