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Targeting FGFR3-Associated Gene Exon Mutations for Therapeutic Intervention

Explore the potential of targeting FGFR3 and TACC3 gene mutations for therapeutic strategies in cancer treatment. Investigate the implications of mutations including EX17 and EX8 and their effects on tumor growth. Utilize insights from EX4 and EX10 mutations in PC9 and K2-49 cell lines. Analyze the significance of EX11 mutations in FGFR3 and TACC3 genes in A549 and H3122 cell lines. Review the impact of mutations on drug sensitivity and resistance using negative controls to guide future research. Examine the genetic variations in FGFR3 and TACC3 through CG-42 sequencing methods.

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Targeting FGFR3-Associated Gene Exon Mutations for Therapeutic Intervention

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  1. FGFR3 EX17 TACC3 EX8 TACC3 EX4 FGFR3 EX17 A B CG-42 A549 Ladder J2-109 H3122 FGFR3 EX17 FGFR3 EX17 TACC3 EX8 TACC3 EX8 PC9 K2-49 Neg FGFR3 EX17 TACC3 EX10 FGFR3 EX17 TACC3 EX11 TACC3 EX11 Figure: S3

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