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Introduction to New High Power High Dose Class IV Laser Therapy. Bruce R. Coren , DVM , MS Founder Class IV Laser Therapy. HDLT-HPLT High Dose – High Power L aser Therapy.

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introduction to new high power high dose class iv laser therapy

Introduction to NewHigh PowerHigh Dose Class IV Laser Therapy

Bruce R. Coren, DVM, MSFounder

Class IV Laser Therapy

hdlt hplt high dose high power l aser therapy
HDLT-HPLT High Dose – High Power Laser Therapy
  • HPLTwas first introduced to the medical field in 2002 by then CEO of Avicenna Laser Technology, Inc, Bruce R. Coren, DVM, MS.
  • The company invented and developed the first High Power Therapeutic Laser to receive FDA clearance in 2003.
TMA– Technological Medical Advancements is a spin off from Avicenna and was founded not only to advance the field of Laser Medicine but also to bring other innovative medical devices to the market place.
  • TMAoffers the most powerful laser platforms in the world and thus allowing physician's of all medical disciplines the capability to heal injuries previously refractive to traditional medical care.
design of the tma laser
Design of the TMA Laser
  • The TMA laser was designed from the ground up to be a therapeutic medical laser.
It was developed using researchby our own biomedical engineers and clinicians as well as collaboration with a major medical school and university optics department.
We investigated important criteria such as wavelength, power and power density, optics and beam deliveryin order to afford the greatest penetration and delivery of a therapeutic dose capable of stimulating tissue healing in deep seated pathologies.

LASER— an acronym for:


Amplification by


Emission of



It could well stand for – Latest Advance For Surgeon to Enhance


surgical lasers in medicine
Surgical Lasers in Medicine

Are used to cut, coagulate, and evaporate tissues. This type of laser replaces the scalpel blade.


The TMA Laser is the only laser available on the market that was designed to accomplishboth surgical and therapeutic procedures.

lasers in medicine
Lasers in Medicine
  • Therapeutic Lasers are used for the stimulation of cell function.
  • The biological effect is photochemical not thermal, as is the case with surgical lasers.
comparison of class iv surgical and therapeutic lasers
Comparison of “Class IV” Surgical and Therapeutic Lasers
  • Surgical lasers collimate high amounts of laser energy into a beam of high intensity resulting in tissue destruction

High Power Therapeutic Lasers take a high amount of laser energy but instead of beam collimation you get beam divergence resulting in tissue stimulation

who is using diowave
Who is using Diowave
  • Veterinarians
  • - Equine and Small Animal
  • Human
  • - Physical Medicine and Rehab
  • - Pain Management
  • - Orthopedists, Neurologists,
  • - Family Practice

Chiropractors and Physical Therapists

  • Podiatrists, Naturopaths and DOM’s
  • College Sports Teams
  • Medical and Veterinary Colleges
  • United States Military
  • VA Hospitals
biological effects of therapeutic lasers
Biological Effects of Therapeutic Lasers
  • Laser therapy aims to bio-stimulate injured and dysfunctional tissues.
  • Clinical studies and trials of Class III & IV laser technology indicate the following beneficial effects of light therapy on tissues and cells.
cellular effects of laser energy
Cellular Effects of Laser Energy
  • Chromophores are components of molecules which absorb light.
The stimulation of chromophoreson mitochondrial membranes incites the production of ATP.
  • Leading to a biological cascade of events.

Increased Growth factor response within cells and tissue as a result of increased ATP and protein synthesis.

  • Accelerated cell reproduction and growth leading to faster repair of damaged tissues.

Increased metabolic activity- via increase in enzyme outputs, oxygen and nutrient availability.

  • Stem cell activation
wound healing effects of laser therapy
Wound Healing Effects of Laser Therapy
  • Faster Wound Healing - Laser significantly increases fibroblast and collagen production which are essential for tissue repair.
  • Improved Vascular Activity - Increased capillary production leads to faster wound closure.
  • .

Greater Tensile Strength - Surgical repaired wounds heal with greater tensile strength, including skin, tendon, ligament and fascia.

  • Scar Tissue Reduction - Wounds heal with less scar tissue formation.
wound healing vet
Wound Healing - Vet



wound healing human
Wound Healing- Human





immune system effects of laser therapy
Immune System Effects of Laser Therapy
  • Strengthening the immune system response via increasing levels of lymphocyte activity and through a newly researched mechanism termed photo-modulation of blood.
acute inflammation reduction
Acute Inflammation Reduction

Stabilization of cellular membrane

Lubart R, Friedman H, and Lavie R. Photobiostimulation as a function of different wavelengths. The Journal of Laser Therapy. Vol12. World Association of Laser Therapy. 2000.

Karu T. et al. Changes in absorbance on monolayer of living cells induced by laser irradiation. IEEE Journal of Selected Topics in Quantum Electronics. IEEE Lasers and Electro-Optical Society. December 2001. 7(6):982.

De Castro E Silva Jr. O, et al. Laser enhancement in hepatic regeneration for partially hepatectomized rats. Lasers in Surgery and Medicine. 2001. 29(1):73-77

acute inflammation reduction1
Acute Inflammation Reduction
  • Acceleration of leukocyticactivity
  • Increased Prostaglandin synthesis
  • Reduction in Interleukin 1(IL-1).
  • Enhanced lymphocyte response
  • Increased angiogenesis
  • Temperature modulation

Acute Inflammation Reduction

Laser Therapy

Cytochrome Activation

Ros Production

Ca, Na, K Ion Changes

Cell Membrane Changes

Proton Gradient Change

ATP Increase


PG Synthesis

IL-1 Decrease

Increased Leukocyte Activity

Enhanced Lymphocyte Response

Temperature Modulation


SOD Production

summary of lt biological effects
Summary of LT Biological Effects
  • Accelerated Tissue Repair
  • Accelerated Cell Growth
  • Faster wound Healing
  • Reduced Scar Tissue Formation
  • Anti-Inflammation
  • Anti-Pain (Analgesia)
summary of lt biological effects contd
Summary of LT Biological Effects contd..
  • Improved Vascular Activity
  • Increased Metabolic Activity
  • Improved Nerve Function
  • Immunoregulation
  • Trigger Point Resolution
  • Acupuncture Pt. Stimulation
summary of lt biological effects contd1
Summary of LT Biological Effects contd..
  • Improved Vascular Activity
  • Increased Metabolic Activity
  • Improved Nerve Function
  • Immunoregulation
  • Trigger Point Resolution
  • Acupuncture Pt. Stimulation
high power high dose laser therapy as it pertains to the spine
High Power - High Dose Laser Therapyas it Pertains to the Spine
  • Decreased inflammation of disc, nerve roots and the caudaequine
  • Increase microcirculation of spinal structures
  • Accelerate healing of annular defects
  • Decreased formation of abnormal/non
  • functional scar tissue

Decreased scar tissue and non-osseous hypertrophic changes

  • Reduce pain associated with PRP –prolotherapyinjection
  • Decrease or even eliminate
  • need for epidurals
high power high dose laser therapy as it pertains to the lower extremities
High Power – High Dose Laser Therapyas it Pertains to the Lower Extremities
  • Decreased inflammation of nerve tissue
  • Accelerated Reinervation of nerve fibers
  • Increase blood flow and microcirculation of tissue structures

Accelerate healing of open wounds

  • Decreased formation of abnormal non-functional scar tissue
  • Increase synovial fluid and cartilage production

Increase collagen and fibroblast production

  • Increase osteoblastic activity and fracture healing
  • Decreased bony edema – osteochondral bone bruise
laser safety overview
Laser Safety Overview
  • Safety Training begins with YOU!
  • Class IV Laser Beams can cause damage to the eyes
  • Safety Glasses must be worn by everyone in the treatment area AKA Nominal Hazard Zone (NHZ)
laser safety
Laser Safety
  • Safety protocols must ensure sufficient precautions are taken to protect the health and safety of employees and patients. Use of safety goggles to prevent retinal exposure is paramount.

Laser Safety

  • Laser safety eyewear is not a primary mode of protection
  • They do not replace proper laser safety education, training, and careful clinical practice.

Laser Safety


Fluorescein angiography

of retina after laser irradiation


Laser Safety

  • Training
  • Equipment Purchase, Service, Quality Assurance
  • Room Design
  • Protective Equipment / Optical

Laser Safety

  • Hazards
  • Routine Procedures
  • Administrative Controls/Management
  • Electrical Hazards

Laser Safety-Reflective Surfaces

  • Medical Instruments (Reflex Hammers, Stethoscope)
  • Jewelry (Rings, Watches, Earrings)
  • Treatment Table
  • Mirrors, Door Knobs and other Fixtures
optical hazards2
Optical Hazards






Laser Classifications

Class 1 Lasers

Compact Disc Players

Laser Printers

laser classifications1
Laser Classifications

Class 2 Lasers

laser classifications2
Laser Classifications

Class 3a Lasers

Office Depot Laser Pointers


Laser Classifications

Class 3b Lasers


laser classifications3
Laser Classifications

Class 4 Lasers

Surgical Lasers

Therapeutic Lasers

human contraindications
Human Contraindications
  • Eyes
  • Carcinoma
  • Hemorrhage
  • Immuno-Suppressant Drugs
  • Sympathetic Ganglia, TheVagusNerves & Cardiac Region In Patients With Heart Disease
  • Pregnant Females
  • Epiphyseal Lines In Children
  • Pacemaker
  • Thyroid, Gonads, & Testicles
  • Light Sensitive Medications
  • Corticosteroids
  • Intolerance
all lasers are not created equally
All Lasers are Not Created Equally
  • Although all therapeutic lasers bio-stimulate tissue, that is where the similarities end.
  • Laser Therapy is all about Physics!
therapeutic laser classifications
Therapeutic Laser Classifications
  • Therapy lasers are classified based on their power output
  • Class IIIa = lasers 1 to 5mw of power (laser pointers)
  • Class IIIb = lasers 6 to 500mw in power

Class IV = lasers above 500mw of power

  • TMA Laser Platforms = 1,000 – 60,000 mw maximum continuous wave output

Clinical Laser Medicine

  • What we would like to do is find a volunteer with knee pain to demonstrate the efficacy of high dose laser therapy
  • While we finish the lecture we will treat the patient and have him/her give you feed back as to how the pain level and range of motion have changed.
the technology
The Technology

Laser Therapy 101

Rule #1:

You Cannot Treat a Target That You Cannot Reach.

the technology1
The Technology

X-Ray Physics = Laser Physics Rule # 2

the technology2
The Technology

Laser Therapy 101

Rule #3:

Overstimulation With Laser Energy Only Exists in a Petrie Dish

the technology3
The Technology

Laser Therapy 101

Rule #4:

Understimulation and Lack of Penetration are the #1 Reasons for Poor Clinical Outcomes!

energy medicine and therapeutic laser physics
Energy Medicine and Therapeutic Laser Physics
  • The therapeutic dosage of laser energy is measured in Joules
  • Dosage is a function of the lasers power output
  • For every one watt of continuous laser power output, one joule of laser energy is delivered per second of time

For a pulsed laser the energy delivery depends on the duty cycle. Duty cycle tells us what percentage of time the laser is on or actively firing. If the duty cycle is 50% then the laser at 1 watt only delivers 0.5 Joules / Second.

  • For any given time period a continuous wave laser delivers twice as much energy than laser with a 50% duty cycle
laser physics
Laser Physics

The shorter the wavelength, the more readily the energy is absorbed in the body.

The higher the wavelength, the deeper the penetration of photon energy.

absorption curve
Absorption Curve

980 nm: Low melanin, low water, low hemoglobin absorption thus an optimal wavelength to choose when designing a therapy laser for stimulating tissue at greater depths of penetration.

physiological effects light tissue interactions
Physiological Effects Light – Tissue Interactions
  • 65% of laser energy is absorbed in the skin and subcutaneous tissue layers with the following having a high affinity for absorption:
    • Hemoglobin in blood
    • Melanin in skin, hair, moles, etc.
    • Water (present in all biological tissue)
how laser light penetrates tissue
How Laser Light Penetrates Tissue
  • As light energy hits the surface of the skin and subsequent deeper layers, some of it is scattered and some of it is absorbed and some is reflected
  • At each tissue interface less energy is available to pass further through to the next layer because of the effects of absorption, reflectance and transmission
laser penetration
Laser Penetration
  • Laser Energy is just another form of energy on the electromagnetic spectrum.
  • Depth of penetration is determined by wavelength and energy density.
  • Just like with x-rays when deeper penetration is required, more energy must be delivered to reach the target tissues.
clinical therapeutic laser penetration
Clinical Therapeutic Laser Penetration
  • Prime Determinants of Laser Penetration and Concomitant Tissue Stimulation are:
  • Power – measured in Watts or milliwatts

Wavelength – measured in nanometers

  • Power Density – measured in mw / cm2
  • Frequency – continuous wave versus pulsing
importance of power density
Importance of Power Density
  • Since approximately 65% of the energy delivered is lost in the epidermis
  • If you don’t start with enough energy on the skin, there will not be enough to stimulate cell healing in deeper tissues

If you do not have sustained power density over a long enough period of time treatments may be ineffective

single wavelength multiple wavelength continuous or p ulsed wave laser
Single Wavelength, Multiple Wavelength,Continuous or Pulsed Wave Laser
  • A laser with two or more wavelengths only has the ability to penetrate as deep as each individual wavelengths allows
  • Most class iv lasers that pulse or have a high duty cycle coupled with multiple wavelengths of energy emission will not penetrate as deep as CW lasers of a single wavelength or lasers that can pulse but still maintain a high average power output
Continuous wave lasers = 100% duty cycle, laser is always delivering energy which is needed to overcome absorption in the superficial layers
  • Newer generation of TMA lasers can now pulse yet still maintain a high average power output allowing for greater tissue saturation with less thermal effects

In Laser Medicine 1 + 1 Does Not Equal 2

  • Dual wavelength lasers only penetrate as deep as each wavelength individually. Penetration is not additive. There is no validated clinical benefit to this scenario. It is more of a marketing

For purposes of penetration it is more advantageous to have one wavelength of greater power that stimulates cell metabolism and tissue regeneration at all tissues densities in its pathway

is there a magical wavelength
Is There A Magical Wavelength?
  • Throughout our 13 years of clinical experience using a 980nm treatment beam, we have experienced stellar results with both superficial and deep pathologies.
  • We still feel once you are treating within the infrared spectrum, power, power density and dosage are the key to better clinical outcomes.

Sponge Theory

  • In order to achieve penetration one must create significant energy density to overcome absorption in the superficial layers of the skin.
  • With low power or pulsed lasers it is like pouring small amounts of water onto a large sponge (the dermis and subcutaneous tissues) and expecting the water to leak through.

In order to do so you must saturate the superficial layers of the sponge- with enough water-energy to soak the sponge-superficial tissue structures

  • So as you pour more water-energy over the sponge it will start to penetrate or leak through.

This it what is needed to penetrate and why it is important to deliver a high amount of laser energy/dosage on the skin

  • Especially if you want to reach deep seated pathologies.

How Much is Enough


Mark D. Skopin and Scott C. Molitor, Department of Bioengineering, University of Toledo, Toledo OH

  • 49-73 mw/cm2 for cell stimulation1
  • This study shows an optimal wavelength (980 nm) and
  • power density range for wound healing and tissue stimulation

Laser & Tissue Powers

Tissue LayerMax Power (mw/cm2)

Epidermis 206

Dermis Layer 182

Dermis Plexus Super. 135

2nd Dermis Layer 115

Dermis Plexus Prof. 93

Muscle Tissue 9.7

Power Setting 5 Watts, 3.0cm spot size, 980nm

This is a snapshot in time. Calculated using computer models by U of Toledo.


Translation – As laser light or energy penetrates through the body more and more energy is absorbed so by the time you start reaching deeper structures there is not enough therapeutic energy to cause adequate tissue stimulation

  • Thus the reason why low power lasers as well as pulsing lasers cannot effectively treat deep seated pathologies.
other factors affecting lasers penetration
Other Factors Affecting Lasers Penetration
  • Duty Cycle – 100%
        • Laser is firing continuously
        • Duty Cycle – 50%
  • Laser is firing 50% of the time. This will not only cut energy delivery but it will also affect ability to penetrate.

Pulsing – Lasers that pulse also do not emit continuous energy

  • Lasers that can operate at 100% continuous wave output or pulse the laser energy while still maintaining a high average power output is key to treating deep seated pathologies and better clinical outcomes.
class iii vs class iv laser beams
Class III vs. “Class IV” Laser Beams

With a high power output the laser beam can easily penetrate deeper joints especially when compared to a class iii laser which at best only offers superficial penetration.

why therapeutic lasers fail
Why Therapeutic Lasers Fail
  • Under penetration - The typical low level or cold laser or weak or pulsed class iv laser does not concentrate the laser energy sufficiently to allow for adequate penetration
Under-dosage – The typical low level or cold laser or weak or pulsed class iv laser does not deliver enough energy to adequately stimulate deep seated inflammatory conditions

TMA protocols are successful because they call for delivery of significantly larger amounts of therapeutic energy than industry standard protocols.

tma diowave philosophy
TMA-Diowave Philosophy
  • TMA’s goal has always been to build the most efficacious laser available to deliver the best outcomes.
  • Our lasers are built from the ground up and are designed to get patients who have failed traditional therapy better

Many other lasers are built based on economic factors or from taking laser from other markets like dentistry and converting them into weak class iv lasers

  • There are no shortcuts to treating deep seated pathologies and one must deliver the correct dosage of laser energy in order to get the best outcomes.
the key to better outcomes
“The Key to Better Outcomes”
  • Higher the power output of laser energy
  • The Greater The Penetration and Dosage
  • The Faster the Therapeutic Outcome

The Quicker the Patient Returns to Normal

  • This is the main reasons we keep advancing our technology and developing more powerful lasers.
why more power is better
Why More Power is Better
  • More power equates to deeper penetration, faster delivery of the proper therapeutic dosage, and ultimately better outcomes
  • A 30 watt laser will not only penetrate deeper, it will put more therapeutic energy to the target pathology
  • It will do this 3X faster than a 10 watt laser and 5X faster than a 12 watt laser with a duty cycle of 50%
recommendations for high dose laser therapy
Recommendations for High Dose Laser Therapy
  • Small Joint – 25-50 lb. Pet = 6,000 Joules
  • Small Joint – 50-100 lb. Pet = 9,000 Joules
  • Large Joint - 25-50 lb. Pet = 9,000 Joules

Large Joint- 50-100 lb. Pet 12-15,000 Joules

  • Equine Dosages are typically Double the Small Animal Dosage for Large Joints
  • Even more for back pathologies
evidence based medicine
Evidence Based Medicine
  • The effects of HPLT can easily be documented
  • Clinician’s can measure results using outcome assessment tools:
      • Pressure Algometer
      • Inclinometer , Goniometer
      • Thermal Imaging and Doppler Studies
      • VAS, PDQ – Pain Disability Questionnaire




MDO = Maximum Diode Output

  • Duty Cycle = Average Time Diodes Are Firing
  • MPTD = Maximum Penetrating Therapeutic Dosage.

Because wavelength and power determine

penetration, and each wavelength penetrates

independently, the maximum penetrating dose

is no greater than the maximum power output

of each diode. With a 50% duty cycle

penetration of each diode gets cut in half.

4. JPM = Joules Per Minute

5. CPW = Cost Per Watt

(Continuous Power Output)


Maximum power output per wavelength is one of the most important factors in favorable treatment outcome.

  • With a dual wavelength laser, laser beam penetration is reduced by 50%; with a 50% duty cycle setting and dual wavelengths, laser penetration is equal ¼ of the stated power output of the laser.

With multiple-wavelength lasers (2-3) beam penetration is reduced even more significantly. If a 50% duty cycle setting is paired with a three-wavelength laser, beam penetration is equal to 1/6 of the stated laser power output.

  • A 10W CW Diowave laser has a stronger maximum diode power output of any therapy laser currently produced.
hplt hdlt a new trend in pain management
HPLT —HDLTA New Trend in Pain Management
  • Profound anti-inflammatory and analgesic effects
  • Pain relief typically immediate
  • Non-invasive and no side effects
  • Profound tissue regeneration of all tissue types
  • Overall contraindications minimal
evidence based medicine1
Evidence Based Medicine
  • The effects of HPLT can easily be documented
  • Clinician’s can measure results using outcome assessment tools:
      • Pressure Algometer
      • Inclinometer , Goniometer
      • Thermal Imaging and Doppler Studies
      • VAS, PDQ – Pain Disability Questionnaire
  • These tools are vital to document outcomes which ultimately lead to adequate reimbursement
applications of laser therapy
Applications of Laser Therapy
  • Disc Pathologies, Spinal Stenosis, Radicular Pain, spondylolesthesis, and sacroiliac dysfunction
  • Failed surgical back syndrome
  • Accelerated Post Surgical, Soft and hard Tissue healing
  • Arthritis (Degenerative Joint Disease)
  • Foot Pain and Neuropathies
  • Muscle, Ligament and Tendon Injuries
  • Ulcerations and Open Wounds
what to look for when purchasing a class iv therapy laser
What to Look For When Purchasinga Class IV Therapy Laser
  • Single wavelength laser
  • True CW (Continuous Wave). Laser will operate all day on CW without issues
  • Highest CW Power
introducing the 2012 tma suite of laser platforms
Introducing the 2012 TMA Suite of Laser Platforms
  • A technological advancement in energy output and delivery
  • The TMA suite of laser platforms offer the world’s most powerful and advanced therapeutic laser system ranging in power output from 10 – 60 watts or 10,000mw -60,000mw.
  • As a veterinary based company we have treated or will know how to treat any condition you are confronted with, the ultimate result being a better outcome
  • With the superior training and clinical support we provide veterinarians, the above goal will readily be achieved
introducing the 2012 tma diowave laser platforms
Introducing the 2012 TMA Diowave Laser Platforms

10 -15 Watt Laser Platform

20 - 30 and 60 Watt Laser Platform

marketing high power laser therapy in veterinary medicine
Marketing High Power Laser Therapy in Veterinary Medicine
  • Laser Therapy is by far the most exciting new clinical treatment to advance veterinary medicine in the 21st century
  • It can also become one of your most significant profit centers in your practice
  • All that’s need to be done to accomplish is to follow the Diowave Turnkey marketing plan that comes with every laser purchase
  • For further information on bringing the a Diowave Laser into your practice you will find our contact information in the next page

In summary my recommendation is to bye the most powerful single continuous wavelength therapy laser you can afford over the next 5 years

  • 15-30 watts for SA
  • 30-60 watts for Equine or Mixed
introducing the 2014 tma diowave high power high dose lasers
Introducing the2014 TMA-DiowaveHigh Power – High Dose Lasers

10-15 Watt Laser Platform

20-30 and 60 Watt Laser Platform

for more information contact the company by
For More Information Contact the Company by:
  • Email –
  • Phone – 866-862-6606

Better Outcomes Are Only a

Phone Call or Email Away