PED 105: ANATOMY & PHYSIOLOGY I. Barbara J. Engebretsen Assistant Professor, HPLS. Terminology. Anatomy Physiology. STRUCTURE & FUNCTION. “Design & Job” “Wings” “Scaffolding” “Molecular Motors”. HOMEOSTASIS.
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PED 105: ANATOMY & PHYSIOLOGY I Barbara J. Engebretsen Assistant Professor, HPLS
Terminology • Anatomy • Physiology
STRUCTURE & FUNCTION • “Design & Job” • “Wings” • “Scaffolding” • “Molecular Motors”
HOMEOSTASIS • Maintaining Life and Health demands an ability to respond to constant disruptions of our internal environment • The Goal of Homeostasis is to maintain a constant internal environment
HOMEOSTASIS • Healthy Balance • “Set Point” • Negative feedback
QUESTIONS: • What is our “internal environment”? • What are some conditions of that environment that must be regulated and maintained?
ANSWERS: • Water!! A 70 kg adult is about 41 liters of H2O: ~8-9% of our body weight
Watery Conditions: Key Variables • Temperature • pH (H+ and OH-) • O2/CO2 • Solutes: NaCl, K+, Ca++... • Nutrients
And More... • Waste Products • Volume • Compartment
Key Terms: Homeostasis • Set Point • Negative Feedback • Sensor (Receptor) • Control Center (911!) • Signal Transduction • Effector
Another Question: • After donating blood, what do you predict will happen to heart rate? • WHY?
Think about: • What is the “set point” condition? • What are the “receptors”? • What is the control center? • What is the “effector”? • This is Negative Feedback!
What if the negative feedback sequences FAIL to return blood pressure to normal? This is BAD: Hypovolemic Shock is a failure of Negative Feedback. Shock is Fatal.
Pathology: Disease • Failure of Negative Feedback or worse: • Positive Feedback • Positive Feedback exceptions: parturition, ovulation
Homeostasis Lab: • Take 10: Read the Lab • Record you pulse: Sit quietly, recording HR for 15 seconds. • Wait 15 seconds, then repeat • Take 10 readings • Multiply your HR by 4 to get minute heart rates
Calculations: • Calculate your average HR: round off to whole number • Graph your average by drawing a red line at that value • Plot each of your readings on the graph
Advanced Thinking: • Calculate the Standard Deviation of your average HR • How “tightly” is your HR controlled? • Find out that average HR for exercisers vs. non-exercisers • Did our data match your hypothesis?
Summary • Define Anatomy/Physiology • Structure/Function Relationships • Homeostasis: Negative and Positive Feedback
Assignment: • Read: Chapter 1:1-9 • Outline sturctural/functional organization (p. 2-3) • Turn in Homeostasis lab