diuretics n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Diuretics PowerPoint Presentation
Download Presentation
Diuretics

Loading in 2 Seconds...

play fullscreen
1 / 27

Diuretics - PowerPoint PPT Presentation


  • 186 Views
  • Uploaded on

Diuretics . Nephron Structure. Diuretics . Drugs that increase the volume of urine flow. How do they works?. Diuretics affect ion transport in the nephron water is carried along with ions passively in order to maintain the osmotic pressure. Classes of diuretics .

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Diuretics' - aron


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
diuretics1
Diuretics
  • Drugs that increase the volume of urine flow
how do they works
How do they works?
  • Diuretics affect ion transport in the nephron

water is carried along with ions passively

in order to maintain the osmotic pressure

classes of diuretics
Classes of diuretics
  • Carbonic anhydrase inhibitors
    • Works on proximal convoluted tubule
  • Loop diuretics
    • Works on thick ascending loop of henle
  • Thiazide diuretics
    • Works on distal convoluted tubule
  • Osmotic diuretics
    • Works on proximal convoluted tubule and collecting duct
  • Potassium sparing diuretics
    • Works on distal convoluted tubule
carbonic anhydrase inhibitor
Carbonic anhydrase inhibitor
  • Acetazolamide
  • CO2 + H2O H2CO3 H+ + H2C
  • Carbonic anhydrase inhibitors cause depletion of H+ decrease in Na abs. Increase water excretoin

Carbonic anhydrase

Exchange with Na+ and cause its reabsorption

clinical uses
Clinical uses
  • Glaucoma
  • Metabolic alkalosis
  • Mountain sickness
  • Epilepsy
  • Not to use as diuretics because of its poor effect
side effects
Side effects
  • Metabolic acidosis
  • Renal stones
  • Sulfa allergy
thiazide diuretics
Thiazide Diuretics

Hydrochlorothiazide

Metolazone

mechanism of action
Mechanism of Action
  • Thiazides freely filtered and secreted in proximal tubule
  • Bind to the electroneutralNaClcotransporter
  • Thiazides impair Na+ and Cl-reabsorption in the early distal tubule: “low ceiling”

Thiazide

therapeutic effects
THERAPEUTIC EFFECTS

Increase Na Excretion

Treatment for

Nephrogenic Diabetes Insipidus

Treatment for

Mild Edema

Treatment for

Hypertension

Treatment for

Renal stones

Decrease Ca Excretion

adverse effects
ADVERSE EFFECTS

Hypercalcemia

Hypokalemia

Hyperuricemia

Hyponatremia

Hyperglycemia

Hypomagnesemia

Hyperlipidemia

Metabolic

Alkalosis

Impotence

loop diuretics

Ethacrynic

Acid

Furosemide

Loop Diuretics
  • Also Called:
    • High Ceiling Diuretics
mechanism of action1
Mechanism of action

The ascending loop of henle

  • Inhibits Na-K-2Cl cotransporter of the ascending loop of henle
therapeutic effects1
THERAPEUTIC EFFECTS

Treatment for

Severe Edema

Increase Na Excretion

Treatment for

Oliguric ARF

Increase Urine Volume

Treatment for

Hypercalcemia

Increase Ca Excretion

Treatment for

Pulmonary Edema

Increase Venous

Capacitance

adverse effects1
ADVERSE EFFECTS

Hypocalcemia

Ototoxicity

Hypokalemia

Metabolic

Alkalosis

Hypomagnesemia

Hyperglycemia

Hyperuricemia

k sparing diuretics
K-Sparing Diuretics

Amiloride

Na inhibitors

1-

Triametrene

Aldosterone antagonist

2-

Spironolactone

mechanism of action of na inhibitors
Mechanism of action of Na+ inhibitors
  • Inhibit Na abs and prevent K excretion
  • Have weak diuretic effects
mechanism of action of aldosterone antagonist
Mechanism of action of aldosterone antagonist
  • Prevent ther action of Na-K pump
therapeutic effects2
THERAPEUTIC EFFECTS

Enhance Natriuresis

Caused by Other Diuretics

Used in Combination with Loop &

Thiazide Diuretics

Prevent Hypokalemia

adverse effects2
ADVERSE EFFECTS

Triamterene

Amiloride

Hyperkalemia

Hyperkalemia

Renal Stones

adverse effects3
ADVERSE EFFECTS

Spironolactone

Hyperkalemia

Gynecomestia

Impotence

Irregular menstrual cycle

osmotic diuretics
Osmotic diuretics

Mannitol

Urea

mechanism of action2
Mechanism of action
  • They create osmotic pressure especially in proximal convoluted tubule and collecting duct
  • No effect on excreting Na+
clinical uses1
Clinical uses
  • In hospital via IV to manage the following situation
    • Increased intracranial pressure
    • Increased intraocular pressure
    • Acute renal failure
adverse effects4
ADVERSE EFFECTS

Hypernatremia

Hypovolemia

Pulmonary edema