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2. Changes When a Cell Becomes Cancer Cell Immortalization. Cancer cells are normal cells that have lost their growth controlTypes of changes:[Fig 28-1]Immortalization: indefinite growthTransformation: deviation from normal growth requirements and constrains; independent of anchorage and serum growth factors, not inhibited by density/contact (grow into focus)Metastasis: invasion of normal tissuesIn vitro culture, normal cells ? Senescence and cease of growth ? CrisisImmortalization af9457

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