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Population Structure Analysis: Tools and Applications

Explore how population structure analysis tools like Structure and Ancestry Models help infer and assign individuals to populations based on genetic data, identifying migrants and admixed individuals for various research purposes.

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Population Structure Analysis: Tools and Applications

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  1. Structure • Infer population structure • Assign individuals to populations • Identify migrants • Identify admixed individuals

  2. How it works • Populations designated by Structure are in H-W equilibrium • Real population structure leads to LD and departures from H-W • Can handle linked markers with linkage map • Uses MCMC • Starts from a random configuration • Steps through parameter space to estimate the probability that predicted “K” = actual “K”

  3. Ancestry Models • No admixture • Use for dominant data • Admixture • Use for most codominant data • An individual may have ancestors in more than one population • Linkage • Use if loci are linked and a linkage map is available • Likely to occur in recently mixed populations • Prior information

  4. Determining populations Codominant data set:Pop1:MEN; Pop2:PLU; Pop3:SANB

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