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第三章 固有结缔组织 Connective Tissue proper

第三章 固有结缔组织 Connective Tissue proper. 重点：. 疏松结缔组织的七种细胞 三种纤维和基质的结构. 结缔组织的结构. 细胞 Cell. 结缔组织 Connective tissue. 基质 Ground substance. 细胞间质 Extracellular matrix. 纤维 Fiber. 组织液 Tissue fluid. 结缔组织的分类 Classification. 固有结缔组织 Connective tissue proper

anika-bennett
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第三章 固有结缔组织 Connective Tissue proper

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  1. 第三章 固有结缔组织 Connective Tissue proper

  2. 重点： • 疏松结缔组织的七种细胞 • 三种纤维和基质的结构

  3. 结缔组织的结构 细胞 Cell 结缔组织Connective tissue 基质 Ground substance 细胞间质Extracellular matrix 纤维 Fiber 组织液 Tissue fluid

  4. 结缔组织的分类 Classification 固有结缔组织 Connective tissue proper 血液和淋巴 Blood and lymph Fluid connective tissue 骨和软骨 Bone and Cartilage Supporting connective tissue

  5. 结缔组织的来源 胚胎时期的间充质 间充质细胞（mesenchyme) 无定形基质 All of CTs originate from mesenchyme embryonic CT

  6. The meshwork of embryonic connective tissue in the mesoderm that gives rise to the connective tissue of the body, blood vessels, and lymph vessels.

  7. 结缔组织的功能 （ Function） 支持，连接，充填，营养， 保护，修复和防御的功能

  8. In a word, CT have functions of connecting, supporting, protecting, nutrition, defense and repairing

  9. 固有结缔组织 Connective tissue proper 疏松结缔组织 Loose connective tissue 致密结缔组织 Dense connective tissue 脂肪组织 Adipose tissue 网状组织 Reticular tissue

  10. 疏松结缔组织 Loose connective tissue Loosely arranged fibers and abundant cells

  11. 成纤维细胞 Fibroblast, 巨噬细胞 Macrophage, 浆细胞 Plasma cell,肥大细胞 Mast cell脂肪细胞 Fat cell, 未分化间充质细胞 undifferentiated mesenchymal cell ,白细胞 Leukocytes. 疏松结缔组织的细胞 Cells in loose connective tissue

  12. ① 成纤维细胞 fibroblast

  13. EM: 粗面内质网 高尔基复合体 游离核糖体 ---function: synthesize fibers and ground substance

  14. Synthesis of collagenous fiber in three steps: a. synthesis of procollagen (RER) → process (Golgi) → procollagen → out of cell b. procollagen→ tropocollagen → fibril c. fibril → collagenous fiber

  15. *fibrocyte:still state or inactive fibroblast ---structure: • spindle-shaped, small • N:small,dark stained • Acidophilic cytoplasma • EM: less organelles ---function:become into fibroblast for repairing

  16. ②巨噬细胞 macrophage

  17. EM: 溶酶体 吞噬体 吞饮小泡 残余体

  18. 功能: 1.趋化性和变形运动 2.吞噬作用 特异性吞噬作用 非特异性吞噬作用 3.参与和调节免疫反应 4.分泌作用

  19. ③浆细胞 plasma cell

  20. EM: rich in parallelly arranged RER, free ribosome and Golgi complex ---function: synthesize and secrete immunoglobulin, Ig-antibody

  21. ④肥大细胞 mast cell

  22. EM Membrane bound granules A few Mitochondria A little RER

  23. 嗜碱性颗粒-----异染性颗粒 • 肝素 （heparin） • 组胺 （histamine） • 嗜酸性粒细胞趋化因子 （eosinophil chemotactic factors of anaphylaxis,ECF-A） • 类胰蛋白酶(tryptase)，胃促胰酶(chymase)， 糜蛋白酶(chymotrypsin) • 白三烯（leukotriene） 功能：引起过敏反应

  24. ⑤脂肪细胞fat cells (adipose cells)

  25. ⑥未分化间充质细胞 undifferentiated mesenchymal cell

  26. ⑦白细胞 leukocytes: 中性粒细胞 neutrophil, 嗜酸性粒细胞 eosinophil ， 嗜碱性粒细胞 basophil 淋巴细胞 lmphocyte 单核细胞 monocyte

  27. summary • A. Classification of CT • B. 7 types of cell in LCT • 1. fibroblast, collagenous fiber synthesis • 2. macrophage, Macrophage & the mononuclear phagocyte system • 3. plasma • 4. mast cell • 5. fat cell • 6. undifferentiated mesenchymal cells • 7. leukocyte

  28. Questions: • 1. Describe the process of collagen fibers’ formation • 2. What kind of cells present in loose connective tissue? And what are the functions of those cells? • 3. What is (are) the structure cell(s) of connective?

  29. 纤维 fibers胶原纤维 Collagenous fiber弹性纤维 Elastic fiber网状纤维 Reticular fiber

  30. 胶原纤维Collagenousfiber (white fiber) LM: 直径1-20 um HE 染色呈粉色，带状

  31. EM: 胶原原纤维 fibrils 20-200nm in diameter 64nm 横纹 胶原蛋白 collagen(type I and III) → 胶原原纤维collagenous fibril → 胶原纤维 collagenous fiber

  32. *formation: Extracellular polymerize collagen(type I and III) collagenous fibril collagenous fiber

  33. 弹性纤维 elastic fiber (yellow fiber) LM: 直径 0.2-1.0 um 特殊染色呈蓝紫色或棕褐色 EM: 弹性蛋白 elastin 微原纤维 microfibril 10-12 nm

  34. 网状状维 reticular fiber LM: 直径0.2-1.0 um 嗜银纤维 Argyrophilic fiber EM: III 型胶原 type III collagen 64nm 横纹 分布： 网状组织，

  35. 基质 ground substance 蛋白多糖 proteoglycan 糖蛋白 glycoprotein 组织液 tissue fluid

  36. ①蛋白多糖 proteoglycan- 糖胺多糖 glycosaminoglycans: 硫酸软骨素 chondroitin sulfate 硫酸角质素 keratin sulfate 硫酸皮肤素 dermatan sulfate 硫酸肝素 heparin sulfate 透明质酸 hyaluronic acid: 2.5um 蛋白 protein *分子筛 molecular sieve

  37. ② 糖蛋白 glycoprotein:纤维粘连蛋白 fibronectin 细胞cells←fibronectin→胶原纤维collagen ↓ 蛋白多糖 proteoglycan ---层粘连蛋白 laminin ---软骨粘连蛋白 chondronectin

  38. ③ 组织液 tissue fluid

  39. 组织 tissue 动脉 artery → 组织液 Tissue fluid → 静脉vein，毛细淋巴管 →血液 blood steam • 脱水 dehydration • 水肿 oedema

  40. 致密结缔组织 Dense connective tissue ---纤维多，细胞少 ---连接 connection ---支持supporting 规则致密结缔组织 Dense regular CT; 不规则致密结缔组织Dense irregular CT 弹性组织 Elastic CT

  41. 规则致密结缔组织 regular DCT:

  42. 不规则致密结缔组织 irregular DCT:

  43. 脂肪组织 adipose tissue ---白色脂肪 white fat T: 单泡脂肪细胞 ---棕色脂肪细胞 brown fat T: 多泡脂肪细胞

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