Sensitization and Agglutination. Antigen-Antibody reaction. Red cell Ag-Ab reaction can detected by a number of techniques Most frequently used Hemolysis Occurs if the entire complement sequence is activated following Ag-Ab interaction Frequently stops at C3 – no lysis Agglutination
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This represents what occurs during stage one of agglutination.
Antibody molecules crosslink RBCs forming a lattice that results in visible clumping or agglutination.
1- Ratio of Ab to Ag
1- Ionic strength of Medium
3- Enzyme treatment of red cells
Clustering of Ags
7- Antibody Characteristics