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On the origin of the genetic code

On the origin of the genetic code. Eörs Szathmáry. Collegium Budapest Eötvös University. The structure of the genetic code. Variants of the common code. Amino acid biosynthesis in E. coli. Coevolution chart. Precursor-product pairs in biosynthesis

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On the origin of the genetic code

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  1. On the origin of the genetic code Eörs Szathmáry Collegium Budapest Eötvös University

  2. The structure of the genetic code

  3. Variants of the common code

  4. Amino acid biosynthesis in E. coli

  5. Coevolution chart • Precursor-product pairs in biosynthesis • Dashed boxes are hypothetical intermediate stages • Italicised codons do not match coevolution predictions

  6. Constraints on codon reshuffling for statistical investigations

  7. 3 ways of code evolution

  8. Forces may have changed in strength

  9. Cofactor use by aptamers

  10. From RNA to protein • Gradual lose of scaffold • Amino acids to peptides to proteins • Not very well worked out

  11. Piecewise evolution of tRNA

  12. Proteins from pieces

  13. Superfolds

  14. Some more proteins

  15. Ribosomal proteins cannot fold by themselves

  16. Tryptophan-binding aptamers

  17. The smallest typtophan binder • The anticodon is CCA • 13 fully conserved nucleotides (26 bits of information) • Selective among hydrophobic changes

  18. An interesting idea? • First two bases of a codon implied in synthesis of amino acids originating from the reductive citric acid cycle

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