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Jinbo Bi. Computer Science and Engineering Department University of Connecticut Email: jinbo@engr.uconn.edu. Machine Learning & Data Mining. Human Behavior Analysis. Genomics of Complex Disease s. Clinical Decision Support. Genetics of C omplex Disease s. Causes

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Jinbo Bi

Computer Science and Engineering Department

University of Connecticut

Email: jinbo@engr.uconn.edu

Machine Learning & Data Mining

Human Behavior Analysis

Genomics of Complex Diseases

Clinical Decision Support

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Genetics of Complex Diseases

Causes

Genetic heterogeneity, gene-environment

Complex phenotypes

Mixture of heterogeneous subtypes

difficult to correlate

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Our project: Identify phenotypic subtypes and subtype-dependent genetic variants

Predictive modeling

Variance analysis

Variance analysis

Association analysis

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Subtyping Method Helps

Based on 9,436 subjects, 68 clinical features and 130 candidate genes ( 1,400 SNPs)

Subtype 4 – Heavy cocaine use, infrequent intravenous injection group

Subtype 5 – Early-onset, heavy cocaine use, high comorbidity group

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References

  • Genomewideassociation study of opioid dependence and related traits: multiple associations mapped to calcium and potassium pathways. Joel Gelernter, Henry R. Kranzler, Richard Sherva, Ryan Koesterer, Jiangwen Sun, Jinbo Bi, Laura Almasy, Hongyu Zhao, Lindsay A. Farrer. In revision of PLoS Genetics, 2013.
  • Comparing the Utility of Homogeneous Subtypes of Cocaine Use and Related Behaviors with DSM-IV Cocaine Dependence as Traits for Association Analysis. Jinbo Bi, Joel Gelernter, Jiangwen Sun and Henry R. Kranzler. To appear in American Journal of Medical Genetics (Part B), 2013.
  • Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors. Jiangwen Sun, Jinbo Bi, Grace Chan, David Oslin, Lindsay Farrer, Joel Gelernter and Henry R. Kranzler. Addictive Behavior, 2012.
  • Multi-view Co-modeling to Improve Genetic Association of Complex Disease Phenotypes. Jiangwen Sun, Jinbo Bi and Henry R. Kranzler. To appear in IEEE Journal of Biomedical and Health Informatics, 2013.
  • Multi-view Biclustering for Genotype-Phenotype Association Studies of Complex Diseases. Jiangwen Sun, Jinbo Bi and Henry R. Kranzler. Submitted to IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2013.
  • A Multi-Objective Program for Quantitative Subtyping of Clinically Relevant Phenotypes. Jiangwen Sun, Jinbo Bi and Henry R. Kranzler. IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2012.