Path Jeopardy. Cellular Responses. Topic 1: 1 point. A 60-year-old man died secondary to a fungal infection of the brain. An autopsy revealed the gross findings in the photograph. Necrosis of the brain is classified as . LIQUIFACTIVE NECROSIS. Topic 1: 2 points.
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activation of caspases through receptor transmitted signals on the cell surface
Dilated cisterns of the rough endoplasmic reticulum
A 60-year-old obese man was admitted to the hospital for treatment of alcoholism. He has diabetes mellitus. A liver biopsy was performed, and the specimen showed that the liver cells contain increased amounts of
This type of calcification occurs in patients who have hypercalcemia, which is most likely caused by secondary hyperparathyroidism
A 48-year-old woman has a malignant lymphoma. She is treated with a chemotherapeutic agent which results in the loss of individual neoplastic cells through fragmentation of cell nuclei and cytoplasm. The lymphoma decreases in size. The mechanism by which her neoplasm primarily responded was
A 53-year-old man has experienced severe chest pain for the past 6 hours. A coronary angiogram is performed and reveals >90% occlusion of the left anterior descending artery. What cellular change seen in irreversible injury will have occurred?
Nuclei undergo karyorrhexis
A 30-year-old man is struck on the leg by a falling path book, which strikes him on his left leg in the region of his thigh. The skin is not broken. Within 2 days there is a 3 x 4 cm purple color at the site of injury. This substance most likely accumulated at the site of injury and produced a yellow-brown color 16 days later
A 54-year-old man with a chronic cough has a squamous cell carcinoma diagnosed in his right lung. During surgery, the hilar lymph nodes are jet black in color. This pigment is the most likely cause for this appearance to the hilar nodes
A 50-year-old woman with a history of unstable angina suffers an acute heart attack. Therapy to restore coronary blood flow is given. In spite of this therapy, the degree of myocardial fiber injury may increase because of this cellular abnormality
Increased free radicals
A 29-year-old man visited the sandy luxurious beaches on Presque Isle State Park. The next day he has a darker complexion. His skin does not show warmth, redness, or tenderness. His skin tone fades to its original appearance within a month. This substance contributes the most to the biochemical process leading to these skin changes
A 55-year-old man has a 30-year history of poorly controlled diabetes mellitus. He has had extensive black discoloration of skin and soft tissue of his right foot, with areas of yellowish soft tissue, for the past 2 months. A below-the-knee amputation is performed. This type of necrosis is called
A 45-year-old man has a traumatic injury to his forearm and incurs extensive blood loss. On physical examination in the emergency department his blood pressure is 70/30 mm Hg. This cellular change is most likely to represent irreversible cellular injury
This is the first manifestation of almost all forms of injury to cells
These are the two principal forms of cell death
Necrosis and Apoptosis
This is the result of denaturation of intracellular proteins and enzymatic digestion of the lethally injured cell
This is a special form of necrosis seen in immune reactions involving blood vessels
A 38-year-old man has a health screening examination. He has a routine chest x-ray that shows a 2 cm nodule in the right lower lobe. The nodule shows caseous necrosis and calcification. The following process explains the appearance of the calcium deposition