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Path Jeopardy. Cellular Responses. Topic 1: 1 point. What are the four components of repair?. Angiogenesis Migration and proliferation of fibroblasts Deposition of ECM Remodeling. Topic 1: 2 points. By 3-5 days of tissue repair, what specialized tissue appears?. Granulation Tissue.

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path jeopardy

Path Jeopardy

Cellular Responses

topic 1 1 point
Topic 1: 1 point
  • What are the four components of repair?
  • Angiogenesis
  • Migration and proliferation of fibroblasts
  • Deposition of ECM
  • Remodeling
topic 1 2 points
Topic 1: 2 points
  • By 3-5 days of tissue repair, what specialized tissue appears?

Granulation Tissue

topic 1 3 points
Topic 1: 3 points
  • What are the two major factors that induce angiogenesis?
  • bFGF (basic fibroblast growth factor)
  • VEGF (vascular endothelial growth factor)
topic 1 4 points
Topic 1: 4 points
  • What are the three phases of cutaneous wound healing?

Inflammation

Proliferation

Maturation

topic 1 5 points
Topic 1: 5 points

This is the simplest type of cutaneous wound repair; healing of a clean, uninfected surgical incision that is then approximated by surgical sutures

Healing by primary intention; primary union

topic 2 1 point
Topic 2: 1 point

This type of cell replaces neutrophils around 48-96 hours during tissue repair

Macrophage

topic 2 2 points
Topic 2: 2 points

This is the most important fibrogenic agent in cell proliferation

TGF-B

topic 2 3 points
Topic 2: 3 points

What are the factors that influence wound healing?

Nutrition

Metabolic status

Circulatory status

Hormones

Infection

Mechanical factors

Foreign bodies

Size, location, and type of wound

topic 2 4 points
Topic 2: 4 points

Excessive formation of collagen that develops following thermal or traumatic injury can give rise to this

Hypertrophic Scar

topic 2 5 points
Topic 2: 5 points

The signaling mechanism by which the cells respond to the signaling molecules that they themselves secrete

Autocrine Signaling

topic 3 1 point
Topic 3: 1 point

This signaling mechanism occurs when one cell type produces the ligand and then acts on adjacent target cells that express the appropriate receptor

Paracrine signaling

topic 3 2 points
Topic 3: 2 points

This signaling mechanism occurs when hormones synthesized by cells of endocrine organs act on target cells distant from their site of synthesis

Endocrine signaling

topic 3 3 points
Topic 3: 3 points

These receptors transmit signals into the cell through trimeric GTP-binding proteins, contain seven transmembraneα-helices, and constitute the largest family of plasma membrane receptors

G-Protein Coupled Receptors

topic 3 4 points
Topic 3: 4 points

This type of growth occurs by enlargement of the lobes of the liver that remain after the operation

Compensatory growth or compensatory hyperplasia

topic 3 5 points
Topic 3: 5 points

This is the most abundant glycoprotein in the basement membrane and it contains binding domains for both ECM and cell surface receptors

Laminin

topic 4 1 point
Topic 4: 1 point

This substance provides resilience and lubrication to connective tissue (notably for the cartilage in joints) and its concentration increases in inflammatory diseases

Hyaluronan

topic 4 2 points
Topic 4: 2 points

These are represented by pale platelet and fibrin deposits alternating with darker red cell-rich layers. It signifies that a thrombus has formed in flowing blood

Lines of Zahn

topic 4 3 points
Topic 4: 3 points

These are thrombi on heart valves resulting from blood-borne bacteria or fungi

Vegetations

topic 4 4 points
Topic 4: 4 points

These are the consequences of shock

The consequences are impaired tissue perfusion and cellular hypoxia

topic 4 5 points
Topic 4: 5 points

This lesion in the maternal pulmonary microvasculature contains squamous cells, lanugo hair, fat from vernixcaseosa, and mucin

Amniotic Fluid Embolism