Aldosterone action in the nephron
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aldosterone action in the nephron. recall our nephron diagram. need to add a new structure. juxtaglomerular cells JUX-ta-glo-MAR-you-lar. sense blood pressure like a collar wrap around afferent arteriole (the arteriole leading to the glomerulus). normal blood pressure.

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Aldosterone action in the nephron

recall our nephron diagram...

need to add a new structure...


Aldosterone action in the nephron

juxtaglomerular cells

JUX-ta-glo-MAR-you-lar

  • sense blood pressure

  • like a collar

  • wrap around afferent arteriole

  • (the arteriole leading to the glomerulus)


Aldosterone action in the nephron

normal blood pressure

low blood pressure

high blood pressure

  • glomerulus works on PRESSURE

  • if blood pressure is too low, filtration won’t happen fast enough

  • urea will stay in the blood

  • blood will become toxic


Aldosterone action in the nephron

blood pressure too low

JG cells release renin

renin activates angiotensin

Na+

angiotensin calls aldosterone

(from adrenal gland)

aldosterone causes increased Na+ reabsorption

blood volume and blood pressure increase

blood gets “saltier”

blood absorbs MORE WATER by osmosis


Aldosterone action in the nephron

angiotensin

adrenal gland

renin

aldosterone

Na+

water enters blood by osmosis


Aldosterone action in the nephron

  • JG cells sense blood pressure (stretch receptors). if BP is too low...

  • JG cells secrete renin

  • renin activates angiotensin

  • angiotensin calls aldosterone (from adrenal cortex)

  • aldosterone causes increased reabsorption of sodium in the DCT

  • increased Na+ causes increased osmosis of water into bloodstream

  • blood volume increases

  • blood pressure increases

  • GFR increases


Aldosterone action in the nephron

blood pressure too low is too low...

JG cells release renin

renin activates angiotensin

Na+

angiotensin calls aldosterone

(from adrenal gland)

aldosterone causes increased Na+ reabsorption

blood volume and blood pressure increase

blood gets “saltier”

blood absorbs MORE WATER by osmosis


Aldosterone action in the nephron

normal blood pressure is too low...

low blood pressure

high blood pressure

  • glomerulus works on PRESSURE

  • if blood pressure is too low, filtration won’t happen fast enough

  • urea will stay in the blood

  • blood will become toxic