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Fundamentals of Nanotechnology. Nanocrystalline Hydroxyapatite. Cornelia Cretiu Vasiliu 12-01-2007. Outline. M otivation M ethods of synthesis C haracterization of structure

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Presentation Transcript
outline
Outline

Motivation

Methods of synthesis

Characterization of structure

Morphology and particle size distribution

Properties & Applications

why nano hydroxyapatite nha
Why nano-Hydroxyapatite (nHA)
  • Bone: 2nd most implanted tissue after blood
  • Protein matrix containing type 1 collagen and minerals
  • Calcium as:

(Ca 2+)10-x(H3O+)2x*(PO4)6(OH-)2

  • Synthetic vs. homo-, allo-, xeno-geneic implants
  • Properties: biocompatibility, biodegradability, mechanical integrity, vascularization inductivity, osteoconductivity, and osteoinductivity

http://www.uabhealth.org/16313

methods of synthesis
Methods of synthesis

HA

Wet methods5

Solid-state reactions6

Sol-gel7

Ellectrocrystallization8

Spray pyrolysis9

Emulsion processing10

Hydrothermal treatment11

nHA

Chemical precipitation1

Hydrothermal treatment12

Microwave synthesis2

To be considered:

stoichiometry, pH, rate of addition, ionic strength

slide5

nHA Methods of synthesis

  • Co precipitation 1)
  • Ca(OH)2 + H3 PO4 nHA
  • Aqueous, pH 8, 38oC
  • Microwave synthesis 2)
  • 10 Ca(OH)2+6 (NH4)2HPO4 Ca10(PO4)6(OH)2+6H2O+12NH4OH
  • 850W, 20 min.
  • 13)Aq. Sol. NaNO3, Ca(NO3)2·4H2O and KH2PO4 precursor
  • 600W, 5 min.
  • stirred in H2O ( room temperature , 1 h) nHA particles.
structure characterization
Structure characterization
  • XRD(1

Powder XRD of the HA precipitate: (a) as-prepared, (b) calcined at 700 °C, (c) calcined at 800 °C, (d) calcined at 900 °C and (e) calcined at 1200 °C. [specific peaks :(H) HAP; (b) β-TCP; (a) α-TCP].( 1

structure characterization 2
Structure characterization (2)

IR(1 spectra of the nHA precipitates:

  • (a) as-dried,
  • (b) calcined at 700 °C,
  • (c) calcined at 800 °C,
  • (d) calcined at 900 °C and
  • (e) calcined at 1200 °C.
particles morphology
Particles morphology

SEM micrograph of the as-prepared nHA(1

TEM micrograph of as-synthesized nano HA crystals(14

particle size distribution
Particle size distribution
  • DLS: Histogram representation of the mean diameters of as-prepared nHA suspended in aqueous solution. (1
applications
Applications

Cell morphology after being cultured for 15 min on the different nHA coated(G2) and uncoated(G1H) titanium surfaces.

Surface roughness decreased(2

nHA doped PLGA composite (30% nHA) hollow fiber membrane fabricated using wet phase inversion technique (13

Coatings

(2

Fibers, tubes

(13

applications1
Applications
  • Bone filler(4
  • Preoperative axial CT
  • (B) Lateral preoperative view
  • (C) After reduction, the remaining defect was filled with nHA paste.
  • (D) Postoperative radiograph
  • (E) 6 weeks after surgery . The patient progressed to full weight bearing at this point in time.
  • (F) 12 months postoperatively, only a marginal loss of correction could be measured.
future developments
Future developments

CT scan

Computer file

Choose customized design

Print, sinter implant

Seed cells, growth factors

Implant

references
References
  • http://www.sciencedirect.com/science/article/B6THV-4JVK567-1/2/501b2d84c7d81d8e9dc5771941065db1 Phase
  • Xiaolong Zhu et al 2006 Nanotechnology17 2711-2721  
  • http://www.sciencedirect.com/science/article/B6TWH-4KY88TT-3/2/2a01537a8d0b528852bb67f079d7e91a Rapid densification
  • F. Huber, J. Hillmeier, N. McArthur, H. Kock and P. J. Meeder, The Use of Nanocrystalline Hydroxyapatite for the Reconstruction of Calcaneal Fractures: Preliminary Results, J. of Foot and Ankle Surgery Vol. 45/ 5, 2006, pp. 322-328.
  • C. Liu, Y. Huang, W. Shen and J. Cui, Biomaterials22 (2001), pp. 301–306.
  • X. Yang and Z. Wang, J. Mater. Chem.8 (1998), pp. 2233–2237
  • W. Feng, L. Mu-sen, L. Yu-peng and Q. Yong-xin, Mater. Lett.59 (2005), pp. 916–919
  • S.K. Yen and C.M. Lin, Mater. Chem. Phys.77 (2003), pp. 70–76.
  • K. Itatani, T. Nishioka, S. Seike, F.S. Howell, A. Kishioka and M. Kinoshita, J. Am. Ceram. Soc.77 (1994), pp. 801–805
  • C.-W. Chen, R.E. Riman, K.S. TenHuisen and K. Brown, J. Cryst. Growth270 (2004), pp. 615–623
  • G.Z. Hui, Z. Qingshan and H.X. Zhao, Mater. Res. Bull.40 (2005) (8), pp. 1326–1334.
  • W.L. Suchanek, K. Byrappa, P. Shuk, R.E. Riman, V.F. Janas and K.S. TenHuisen, J. Solid State Chem.177 (2004), pp. 793–799
  • N. Zhang et al. / Materials Science and Engineering C 27 (2007) 599–606
  • S. Ramesh et al. / Ceramics International 33 (2007) 1363–1367
questions
Questions?

HA:βTCP

60:40

1270oC/4h

HA:βTCP

60:40

1100oC/4h