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Decrease in Contralateral Breast Cancer Incidence After First RO+ Breast Cancer

This study analyzes the annual changes in the contralateral breast cancer incidence after the first RO+ breast cancer. The cumulative absolute risk of contralateral cancer is examined in relation to family history and BRCA mutations.

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Decrease in Contralateral Breast Cancer Incidence After First RO+ Breast Cancer

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  1. Baisse d’incidence du cancer controlatéral (CCL) 1,0 1,0 CCL après premier cancer du sein RO+ CCL après premier cancer CCL après premier cancer du sein RO- 0,8 0,8 EPCA = 0,27 %/an (écart : -0,4 à 0,9) EPCA = 1,68 %/an (IC95 : 0,0 à 3,4) EPCA = 3,07 %/an (IC95 : -0,4 à -2,7) 0,6 0,6 HR (% par an) HR (% par an) 0,4 0,4 0,2 0,2 1985 EPCA = -3,18 %/an (écart : -4,2 à -2,2) 0 0 1980 1990 2000 1980 1990 2000 Année du diagnostic du premier cancer Année du diagnostic du premier cancer EPCA : estimation du pourcentage des changements annuels. D’après Nichols HB et al., J Clin Oncol 2011;29(12):1564-9

  2. Risque cumulé absolu de cancer controlatéral chez les femmes de moins de 55 ans au premier diagnostic 30 1 cas, filiation premier degré Cas bilatéral, filiation premier degré 25 1 cas, filiation deuxième degré Pas d’antécédent familial 20 Porteuses de mutations BRCA 1 ou 2 Risque cumulé absolu (%) 15 10 5 0 1 2 3 4 5 6 7 8 9 10 Intervalle depuis le premier cancer (années) D’après Nichols HB J Clin Oncol. 2011 Apr 20;29(12):1564-9

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