Coronary Calcification; Body Mass Index (BMI) or Waist to Hip Ratio (WHR) - PowerPoint PPT Presentation

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Coronary Calcification; Body Mass Index (BMI) or Waist to Hip Ratio (WHR)
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Coronary Calcification; Body Mass Index (BMI) or Waist to Hip Ratio (WHR)

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  1. Coronary Calcification; Body Mass Index (BMI) or Waist to Hip Ratio (WHR) Siamak Sabour, MD, MSc, DSc, PhD, Postdoc Clinical Epidemiologist Persian International Epidemiology Network (PIEPNET)

  2. SCIENTIFIC BACKGROUND • 1994:M.D, I.R. Iran • 2004:M.Sc, Clinical Epidemiology, Erasmus MC, The Netherlands • 2006:D.Sc, Clinical Epidemiology, Erasmus MC, The Netherlands • 2007:Ph.D, Clinical Epidemiology, UMC Utrecht, The Netherlands • 2008 • Post doc Cardiovascular Epidemiology Thomas Jefferson University, Philadelphia, PA, USA • Post doc Pharmacoepidemiology University of Pennsylvania, Philadelphia, PA, USA • 2008 until now Assistant Prof of Clinical Epidemiology & Medicine Sabous S, MD, MSc, DSc, PhD, Postdoc

  3. PURPOSE To examine the relation between 9 years change in Body Mass Index (BMI), Waist-to-Hip Ratio (WHR) and risk of coronary artery calcification (CAC). Sabous S, MD, MSc, DSc, PhD, Postdoc

  4. DESIGN Longitudinal study Sabous S, MD, MSc, DSc, PhD, Postdoc

  5. SUBJECTS 573 postmenopausal women selected from a population based cohort study. Sabous S, MD, MSc, DSc, PhD, Postdoc

  6. METHODS Data on BMI & WHRwere collected at baseline (1993-1997) and follow-up (2002-2004). At follow-up, the women underwent a multi-detector computed tomography (MDCT) (Philips Mx 8000 IDT16) to assess coronary artery calcium (CAC). Sabous S, MD, MSc, DSc, PhD, Postdoc

  7. METHODS The Agatston score was used to quantify coronary artery calcium. Logistic regression models were used to evaluate the relations under study. Sabous S, MD, MSc, DSc, PhD, Postdoc

  8. METHODS Change in BMI & WHR was categorized into four groups: • Low at baseline-Low at follow-up (low was defined as below the median) • High-Low • Low-High • High-High Sabous S, MD, MSc, DSc, PhD, Postdoc

  9. RESULTS Compared to subjects whose WHR remained below the median of the distribution at both occasions, those with a WHR above the medianat both occasions had a 2.8 [95% CI 1.5 - 5.7] fold increased risk of CAC. Sabous S, MD, MSc, DSc, PhD, Postdoc

  10. RESULTS Women whose WHR rose over the 9 year period from below the median to above the median had a 2.6 [95%CI 1.3 - 5.2] fold increased risk of CAC. Sabous S, MD, MSc, DSc, PhD, Postdoc

  11. RESULTS In contrast, change in BMI was notrelated to risk of CAC. Sabous S, MD, MSc, DSc, PhD, Postdoc

  12. Sabous S, MD, MSc, DSc, PhD, Postdoc

  13. CONCLUSION Change in WHR over time relates to an increased risk of CAC. However, BMI has no effect on that. Sabous S, MD, MSc, DSc, PhD, Postdoc

  14. Acknowledgments Prof. Diederick. E. Grobbee, MD, PhD Prof. Mathias Prokop, MD, PhD Dr. Yvonne. T. van der Schouw, PhD Prof. Michiel. L. Bots, MD, PhD 1. Julius Centre, University Medical Centre Utrecht, The Netherlands 2. Radiology Department, University Medical Center Utrecht, The Netherlands Sabous S, MD, MSc, DSc, PhD, Postdoc

  15. CONCLUSION Changes in Waist-to-Hip Ratio (WHR) relates to an increased risk of CAC. However, Body Mass Index (BMI), has no effect on that.