Suggested HW Ch. 5. 1 – 9 (Chapter 5.1, 5.2) Note: Protein Explorer (originally due Friday) delayed. K d. What is the definition of K d ?
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Four bind heme nitrogens
One binds protein histidine
One can bind O2
Distal His binds oxygen
for carbon monoxide
CO still preferred over O2
allows O2 exit &
“Three-over-three a-helical sandwich”
Hemoglobins, myoglobins, cytoglobins, etc
Myoglobin•O2 ↔ Myoglobin + O2
Hyperbolic dependence of O2 binding on pO2