the utility of new open-access resources for tracking down chemical structures of protein-protein interaction inhibitors

Aug 24, 2011

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the utility of new open-access resources for tracking down chemical structures of protein-protein interaction inhibitors

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Protein-protein interaction

Protein-protein interaction. Data sets and comparisons Roland Krause. Outline. Important data sets of protein-protein interaction Comparison of data sets in yeast Overview of current methods Suggested modifications. Biochemical purifications Yeast Gavin et al. (2002) Nature

588 views • 15 slides

Protein structures

Protein structures. Haixu Tang School of Inforamtics. A covalent peptide bond . Protein conformation is specified by tts Amino Acid sequence . Steric interactions Weak non-covalent bonds hydrogen bonds ionic bonds van der Waals attractions Hydrophobic interaction

605 views • 24 slides

Protein Complex and Protein-protein Interaction

Protein Complex and Protein-protein Interaction. 彭鲲鹏国家人类基因组北方研究中心 Email: pengkp@yahoo.com.cn. Central dogma: the story of life. Protein is the final player in cell life. DNA. RNA. Protein. Proteins function in association with other proteins or biomolecules, but not in isolation.

1.11k views • 65 slides

Bacteriostatic Inhibitors of Protein Synthesis

Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Linezolid, Dalfopristin/Quinipristin, Spectinomycin. Bacteriostatic Inhibitors of Protein Synthesis. Tetracyclines. Broad spectrum All agents similar in terms of action & adverse effects Main differences are pharmacokinetic

804 views • 45 slides

Protein Synthesis Inhibitors

Protein Synthesis Inhibitors. BY S.Bohlooli , PhD School of Medicine, Ardabil University of Medical Sciences. Protein Synthesis Inhibitors. Tetracyclines Amimoglycosides Macrolides Clindamycin Chloramphenicol Streptogramines Oxazolidinones. Tetracycline.

990 views • 61 slides

An Ontology for Protein-Protein Interaction Data

An Ontology for Protein-Protein Interaction Data. Karen Jantz CIS Honors Project December 7, 2006. Overview. Problem Statement Objectives Approach Background Methodology Evaluation Demonstration Conclusion. Problem Statement. Several sources for protein-protein interaction data

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Protein Structures

Protein Structures. Primary structure Amino acid sequence Edman degradation, MS, deduce from DNA Secondary structure Recurring structural pattern Circular dichroism (CD, 圓二色極化光譜儀 ) Tertiary structure 3D folding of a polypeptide chain X-ray crystallography, NMR Quaternary structure

3.71k views • 35 slides

Protein Synthesis Inhibitors

Protein Synthesis Inhibitors. Tetracyclines Macrolides Chloramphenicol Aminoglycosides Clindamycin Streptogramins. Alan M. Reynared, Ph.D. QUICK REVIEW - Protein Synthesis. Tetracyclines - Structure. Excretion R 1 R 2 R 3 R 4 mg/hr

1.08k views • 35 slides

Protein – protein interaction

Protein – protein interaction. Modular Organization of Protein Interaction Network. Biological Systems. Made of many non-identical elements connected by diverse interactions. Biological Networks. Biological Networks. Biological networks as framework for the study of biological systems.

1.42k views • 81 slides

Protein-Protein Interaction Network

Protein-Protein Interaction Network. Gautam Chaurasia 08.07.04. Overview. Introduction. Three Different Models : Structure of the protein-protein interaction network. Non-power law. Evolutoin of the network. Power Law Random Graphs.

1.02k views • 46 slides

CLASSIFICATION AND CHARACTERIZATION OF NATURAL PROTEIN INHIBITORS OF PROTEIN KINASES

CLASSIFICATION AND CHARACTERIZATION OF NATURAL PROTEIN INHIBITORS OF PROTEIN KINASES AGATA MEGLICZ 1 , JACEK LELUK 1 , BOGDAN LESYNG 1,2 1 Interdisciplinary Centre for Mathematical and Computational Modelling (ICM), Warsaw University, Poland

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PROTEIN SYNTHESIS INHIBITORS

PROTEIN SYNTHESIS INHIBITORS. INTRODUCTION. These antibiotics exert their actions by targeting the bacterial ribosomal subunit at various steps in the synthesis of bacterial protein. Bacterial ribosome is smaller 70 s as compared to the mammalian cytoplasmic ribosome - 80 s.

3.42k views • 39 slides

Inhibitors of Protein Synthesis

Inhibitors of Protein Synthesis. Bacterial cells are 50% protein by dry weight Inhibition of protein synthesis leads to cessation of growth or cell death Bacterial 70S ribosomes differ sufficiently from eukaryotic ribosomes to allow selective toxicity

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Detection of Protein-Protein Interactions Using the GST Fusion Protein Pull-down Technique

Detection of Protein-Protein Interactions Using the GST Fusion Protein Pull-down Technique. Bacterially expressed glutathione S-transferase (GST)-fused proteins are used as probes to perform direct measure of protein-protein interactions and for affinity purification.

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Protein Design Based on the Designability of Protein Structures

Protein Design Based on the Designability of Protein Structures. Chen Zeng, PI (GWU) Chao Tang, Co-PI (NEC) Ned Wingreen (Princeton) Naigong Zhang (GWU) Luhua Lai (PKU) NSF Support: DMR-0094176, 0313129. Protein Folds (~1000! Why so small?). Acylphosphatase. Ribosomal protein S6.

348 views • 13 slides

Protein Structures

Protein Structures. Ramachandran plot. Shows grouping of φψ combinations and relates them to structures in real proteins Repetitive structures (  - helices,  -sheets) are common.  -helix. • 3.6 amino acids per turn • 0.54 nm per turn • side chains pointed out

247 views • 21 slides

Protein Synthesis Inhibitors

424 views • 35 slides

Bacterial protein synthesis inhibitors

Bacterial protein synthesis inhibitors. Haitham Mahmood Alwali Ph.D Pharmacology Al-Nahrain College of Medicine. The mechanisms of protein synthesis in microorganisms are not identical to those of mammalian cells. Bacteria have 70S ribosomes , whereas mammalian cells have 80S ribosomes .

868 views • 40 slides

Inhibitors of protein synthesis

Inhibitors of protein synthesis. Macrolides Tertracyclines Aminoglycosides Chloramphenicol. MACROLIDES. Mechanism of action : Inhibits protein synthesis by binding to 50S ribosomal subunits Bactericidal at high concentration & bacteriostatic at low concentration. Erythromycin

541 views • 45 slides

Protein structures

Protein structures. Protein Structure. Why protein structure? The basics of protein Basic measurements for protein structure Levels of protein structure Prediction of protein structure from sequence Finding similarities between protein structures Classification of protein structures.

1.34k views • 123 slides

Protein Synthesis Inhibitors

Protein Synthesis Inhibitors. Tigecycline: a derivative of minocycline, is the first available member of the glycylcycline antimicrobial class. Complicated skin and soft tissue infections. Complicated intra-abdominal infection. Bacteriostatic action. Broad-spectrum activity.

391 views • 19 slides

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