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New Delivery Systems from Dow Corning. December 2005. Desired result: 3 take-aways. Why Dow Corning is committed to providing you with the broadest range of delivery system technologies

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desired result 3 take aways
Desired result: 3 take-aways
  • Why Dow Corning is committed to providing you with the broadest range of delivery system technologies
  • Our existing technologies, our resources to customize solutions that meet your formulating needs exactly, and where we’ll continue to invest
  • The strength of our in-house experts and alliance partners
agenda
Agenda
  • Strategic insight into the Life Sciences business
  • Deliver the Difference — the vision for our delivery systems technologies portfolio
  • Technical overview
    • Phospholipid-based Vesicles
    • Silicone Vesicles
    • Micro-encapsulation
    • Silicone Elastomer Blends
strategic insight
Strategic Insight
  • Our Life Science’s vision is to improve the quality of life in the markets we serve
  • Our mission is to be your ideal supplier of performance enhancing materials — including those that deliver active ingredients
  • Our objective is to collect and offer various, diverse delivery technologies
strategic insight5
Strategic Insight
  • Our strategy is highly integrated and includes but is not limited to:

- Relying on our 60+ year heritage designing and formulating functional specialty chemicals

- Exploiting our global supply chain that reliably delivers the highest quality material

- Leveraging our strong customer relationships to collaborate and innovate custom solutions-

the benefit to you
The Benefit to You
  • “One stop” shopping — materials, technical support, formulating expertise, application knowledge, EHS documentation, analytical services, performance testing capabilities, customized solutions on a global scale
  • A broader choice of ingredients that — in combination with silicones — promote synergistic performance benefits
next steps
Next steps

Developing a delivery systems technologies portfolio

is a journey, not a destination!

why delivery systems
Why Delivery Systems
  • The market’s growing at a double digit rate
  • Consumers demand convenience (multifunctionality), healthful/youthful appearance (well being), natural ingredients (vitamins, botanicals) and environmental protection (antioxidants, UV/sun blocks) — active ingredients can meet these expectations
  • Delivery technologies are formulation specific — few suppliers are consolidating multiple technologies under one offering
alliances and partnerships
Alliances and Partnerships
  • Silicone-based technologies have some intrinsic limitations and cannot meet all of the key market needs by themselves
  • In order to fulfill our vision of a global, world-class delivery systems provider we sought leading edge technology partners to fill the gap
  • Lipo Chemicals, Inc. and Lipo Technologies, Inc. and Dow Corning have formed an alliance to offer micro-encapsulation technologies as part of our offering
introducing four delivery technologies
Introducing Four Delivery Technologies
  • Phospholipid-based Vesicles
  • Silicone Vesicles
  • Micro- and milli- encapsulation Systems
  • Silicone Elastomer Blends
slide13
Phospholipid-based Vesicles

Dow Corning® Liposomes

dow corning liposomes
Dow Corning® Liposomes
  • Combined effect of a high level of phosphatidylcholine and high level of dilinoleoylphosphatidylcholine
    • Soy bean lecithin = GMO free
    • Unilamellar liposomes
    • Physical and chemical stability
    • Penetration of the upper layers of skin
  • Innovative testing capabilities to prove vitamin stability, efficacy and penetration (ESR)
dow corning liposomes15
Dow Corning® Liposomes

Penetrating Liposome System

  • Penetrating line designed to supply cosmetic actives in the upper layers of the skin

Non-Penetrating Liposome System

  • Non-Penetrating line designed to supply cosmetic actives on the surface of the skin
  • Penetration is prevented by the use of a sterically hindered triglyceride

Commercially available loaded with a variety of cosmetic actives with the possibility for customization

dow corning silicone vesicles
Dow Corning® Silicone Vesicles
  • Silicone vesicles are hollow particles with water at the exterior and interior, and a bilayer that contains the particle.
  • Capable of encapsulating both lipophilic and hydrophilic actives.
  • New “assembly-required” vesicles developed with attractive morphologies.
dow corning silicone vesicles18
Dow Corning® Silicone Vesicles

Two silicone vesicles are currently under development based on:

  • rake SPE
  • (AB)n SPE

Actives encapsulated:

  • Vitamins (vitamin A palmitate, vitamin C)
  • Sunscreens, and
  • Fragrances.

Stability of Si vesicle encapsulated actives demonstrated.

Encapsulation of customer’s specific actives possible.

lipocapsules
Lipocapsules®
  • Limitations
  • Water insoluble IP only
  • Soften at pH 8.5 and higher
  • Permeable to solvents
  • Residue after rupture
  • No dry over 500 microns
  • Filling requirements
  • Advantages
  • Separation of Incompatibles
  • Target or Sustained Release
  • Prevent Oxidation
  • Improve Flow Characteristics
  • Convert Liquids to Solids
  • Improved Aesthetics
  • Supplied slurry, cake or dry powder
  • Gelatin Lipocapsules®
  • Animal Derived (Gelatin)
  • CMC – Gum Arabic-Carrgeenan
  • 10-3000 microns average diameter
  • 50 – 97% Internal phase
  • PMU Lipocapsules®
  • Synthetic Derived
  • Polyoxymethylene Urea
  • Methoxymethyl Methylol Melamine
  • 5 –100 microns average diameter
  • 50-80% Internal Phase
  • Limitations
  • Water insoluble IP only
  • Soften at pH 8.5 and higher
  • Fragile at sizes > 100 microns
  • Residue after rupture
  • Filling requirements
lipospheres
Lipospheres®
  • Agar
  • Polysaccharide
  • 500 – 400 microns
  • 25% Internal Phase
  • Alginate
  • Calcium Alginate
  • 500-4000 microns
  • 25% Internal Phase

Gellan

  • Heteropolysaccharide
  • 500-4000 microns
  • 25% Internal Phase
  • Advantages
  • Vegetable derived
  • Water soluble IP capable
  • Water insoluble IP capable
  • No residue after rupture
  • Target or sustained release
  • Improved aesthetics
  • Limitations
  • Solvent permeable
  • Slurry only
  • Reversible reaction
  • Fillingrequirements
  • Limitations
  • Solvent permeable
  • Slurry only
  • Filling requirements
  • Limitations
  • Solvent permeable
  • Slurry only
  • Filling requirements
lipobead
Lipobead™

Vegetable Derived

  • Mannitol
  • Cellulose
  • HPMC
  • 700 & 1500 microns Average
  • 5% Internal Phase
  • Animal Derived
  • Lactose
  • Cellulose
  • HPMC
  • 700 & 1500 microns Average
  • 5% Internal Phase
  • Advantages
  • Water soluble IP capable
  • Water insoluble IP capable
  • Supplied as dry prills
  • Extended hydration time
  • No residual after rupture
  • Target or sustained release
  • Improved aesthetics

Limitations

Solvent Permeable

lipoparticle
Lipoparticle™

Vegetable Derived

  • Cellulose
  • Cyclodextrins
  • 5-500 Microns Average
  • 30% Internal Phase
  • Synthetic
  • Nylon 12
  • 5-500 Microns Average
  • 30% Internal Phase
  • Advantages
  • Water soluble IP capable
  • Water insoluble IP capable
  • Convert liquids to solids
  • Substrate for overcoat
  • Substrate for granulation
  • Target or sustained release
  • Improve flow characteristics

Limitations

Solvent Permeable

Dispersion considerations

dow corning silicone elastomer blends

Cosmetic Fluids

Si elastomer

Si elastomer

Actives

Actives

Dow Corning® Silicone Elastomer Blends
  • A crosslinked silicone elastomer gel particle swollen in various cosmetic fluids.
  • The unique fluid-in-gel particle offers a very desirable smooth, silky skin feel.
  • Soft gel particles of 20 – 80 um size.
  • Two options to incorporate actives:
    • Post-loading:
    • Pre-loading:
dow corning silicone elastomer blends26
Dow Corning® Silicone Elastomer Blends
  • Actives investigated: vitamins, fragrances and sunscreens.
  • Stability in both pre- and post-loaded SEBs and cosmetic formulations.
  • Excellent skin sensory feel retained in active-entrapped SEBs.
for more information please contact lifesciences@dowcorning com

For More Information Please Contactlifesciences@dowcorning.com