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Integrated Substance Abuse Programs

Integrated Substance Abuse Programs. Bridges have been built: Is anyone using them? Richard A. Rawson, Ph.D, Professor Supported by: National Institute on Drug Abuse (NIDA) Pacific Southwest Technology Transfer Center (SAMHSA) United Nations Office of Drugs and Crime .

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Integrated Substance Abuse Programs

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  1. Integrated Substance Abuse Programs Bridges have been built: Is anyone using them?Richard A. Rawson, Ph.D, ProfessorSupported by: National Institute on Drug Abuse (NIDA) Pacific Southwest Technology Transfer Center (SAMHSA) United Nations Office of Drugs and Crime

  2. The Problem in 1996 • The US Substance Abuse Research and Treatment Systems each spend billions of dollars per year on the problem of substance abuse treatment. • However, the efforts have traditionally been completely disconnected. Despite over 30 years of research findings, most treatment services are based on practices developed during the 1950s and 1960s.

  3. U.S. Agencies Involved with Substance Abuse Research and Treatment Research Agencies NIH National Institutes of Health NIDA National Institute on Drug Abuse NIAAA National Institute on Alcohol Abuse & Alcoholism

  4. U.S. Agencies Involved with Substance Abuse Research and Treatment Service Agencies SAMHSA Substance Abuse, Mental Health Services Administration CSAT Center for Substance Abuse Treatment CSAP Center for Substance Abuse Prevention

  5. Traditional “Culture” of U.S. Substance Abuse RESEARCH System • University-based, academic personnel • Minimal community involvement • Treatment viewed condescendingly • Publish data in professional journals • Little systematic attempt to transfer knowledge • Topics of research omit clinical concerns

  6. Traditional “Culture” of U.S. Substance Abuse SERVICE Delivery System • Recovering/paraprofessional staff • Minimal connections with academic tradition • Personal ideology determines treatment choices • Generally anti-medication • Uneven and inadequate treatment funding • Little attention to data • Science viewed as irrelevant

  7. “Bridging the Gap”: A Benchmark • Institute of Medicine (1998). S. Lamb, M.R. Greenlick, & D. McCarty, D. (Eds.), Bridging the gap between practice and research: Forging partnerships with community-based drug and alcohol treatment. Washington, DC: National Academy Press.

  8. THE NATIONAL INSTITIUTE ON DRUG ABUSE (NIDA) CLINICAL TRIALS NETWORK (CTN)www.nida.nih.gov/CTN

  9. NIDA Clinical Trials Network (CTN) • MissionThe mission of the Clinical Trials Network (CTN) is to improve the quality of drug abuse treatment throughout the country using science as the vehicle.The CTN provides an enterprise in which the National Institute on Drug Abuse, treatment researchers, and community-based service providers cooperatively develop, validate, refine, and deliver new treatment options to patients in community-level clinical practice. This unique partnership between community treatment providers and academic research leaders aims to achieve the following objectives: • Conducting studies of behavioral, pharmacological, and integrated behavioral and pharmacological treatment interventions of therapeutic effect in rigorous, multi-site clinical trials to determine effectiveness across a broad range of community-based treatment settings and diversified patient populations; and • Ensuring the transfer of research results to physicians, clinicians, providers, and patients.

  10. The NIDA CTN: What is it? • Network Organization • The CTN framework consists of seventeen Nodes (Regional Research and Training Centers, linked with five to ten or more Community-based Treatment programs), a Clinical Coordinating Center, and a Data and Statistical Center.  • This allows the CTN to provide a broad and powerful infrastructure for rapid, multi-site testing of promising science-based therapies and the subsequent delivery of these treatments to patients in community-based treatment settings across the country.

  11. The Pacific Node of the CTN • The Pacific Region Node is a partnership between the Regents of the University of California, Los Angeles and several community treatment programs in the State. • The Pacific Node incorporates researchers and clinicians from throughout California. Many of the clinical networks have been involved in the transfer of research into practice for over a decade

  12. NIDA CTN: How does it work? • Research concepts are generated at each of the Nodes after discussion between researchers and clinicians. • These concepts are proposed to the CTN group and are voted on. Those receiving highest vote go to director of NIDA for approval.

  13. Pacific Region Protocol Involvement PROTOCOL0001 Buprenorphine/Naloxone for Opiate Detoxification - INpatient • PROTOCOL0002 Buprenorphine/Naloxone for Opiate Detoxification - OUTpatient • PROTOCOL0004 Motivational Enhancement Treatment (MET) • PROTOCOL0006 Motivational Incentives - Drug Free Clinics • PROTOCOL0007 Motivational Incentives - Methadone Clinics • PROTOCOL0008 A Baseline for Investigating Diffusion of Innovation

  14. Pacific Region Protocol Involvement • PROTOCOL0009 Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy In Substance Abuse Rehabilitation Programs • PROTOCOL0012 Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs • PROTOCOL0014 Brief Strategic Family Therapy (BSFT) For Adolescent Drug Abusers

  15. Pacific Region Protocol Involvement • PROTOCOL0018 Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment • PROTOCOL0019 Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment • PROTOCOL0027 Starting Treatment with Agonist Replacement Therapies – START • PROTOCOL0030 Prescription Opioid Addiction Treatment Study (POATS)

  16. CTN: Strengths • Has provided a true forum for researchers and clinicians to interact cooperatively and collaboratively • Has generated a significant amount of new published research • Research and surrounding publications do appear to be promoting some transfer of research to practice in CTN-affiliated treatment organizations • Annual “Blending” Conference and Journal

  17. CTN: Limitations (opinion) • Extremely expensive • Extremely bureaucratic and committee heavy • Productivity not commensurate with budget • Bi-directionality of effort is only moderately successful (mostly researcher driven) • Impact on the larger US treatment system is unknown

  18. Running the Trials is not enough • Diffusion of Innovations. 4th Edition • Everett M. Rogers - 1995 - New York: Free Press

  19. Research Questions • NIDA’s CTN offers an important opportunity to examine if and how inter-organizational relationships promote innovation adoption • Focus on buprenorphine and voucher-based motivational incentives • Are CTPs in the CTN protocols significantly more likely to adopt bup and/or vouchers? • Is “trialability” a predictor of adoption? • Does membership in the CTN confer advantages to CTPs that are not involved in these protocols? • Is “exposure” a predictor of adoption?

  20. Adoption of Buprenorphine CTPs that participated in the buprenorphine trials were significantly more likely to have adopted buprenorphine than CTPs not in the trials and non-CTN centers

  21. Logistic Regression Model of Buprenorphine Adoption • Controlling for other organizational factors: • CTPs in the buprenorphine protocols were 5.2 times more likely to use buprenorphine (at the 6-month follow-up) than non-CTN programs (p<.01) • Other significant predictors, net of effects of CTN exposure: • Center offers detox services (O.R. = 3.59) • Center has a physician on staff or contract (O.R. = 3.94) • The percentage of primary opiate clients (O.R. = 1.009)

  22. Adoption of Voucher-Based Motivational Incentives These differences in adoption were not statistically significant

  23. Discussion • The ability to compare CTN vs. non-CTN centers provides a unique opportunity to examine a variety of factors that influence innovative behavior and the adoption of evidence-based practices at the organizational level. • The longitudinal design of these studies will allow for observation of continued trends in adoption of these techniques. • Future research is planned to examine the use of MET and motivational interviewing in CTN and non-CTN samples.

  24. From a clinical trial to technology transfer • S. Kellogg, M. Burns, P. Coleman, M. Stitzer, J. Wale, M. Jeanne Kreek, M.D. • Something of value: The introduction of contingency management interventions into the New York City Health and Hospital Addiction Treatment Service.  • Journal of Substance Abuse Treatment, 2005, Volume 28, Issue 1, Pages 57-65

  25. The NIDA Methamphetamine Clinical Trials Group (MCTG)

  26. MCTG: The Problem • NIDA has a desire to speed up the development of medications for the treatment of methamphetamine use disorders. • Too few research groups available in areas of the US with extensive methamphetamine use. • As complexity of medication testing and regulatory system becomes more complex it is difficult for new investigators to initiate research

  27. MCTG: The Solution • Establish a training/coordinating center to train, organize and monitor sites. • Establish a set of medication testing sites in regions with extensive methamphetamine use and an MD and team that can conduct trials. • Decide on a medication(s) and protocol for study • Initiate studies

  28. Methamphetamine Clinical Trials Group • UCLA is the coordinating center for clinical studies • 5 Sites participate on a contractual basis • Primary focus-reduction of methamphetamine use • All trials use a behavioral platform for all treated subjects

  29. Costa Mesa, CA Friends Research Institute Michael McCann, PI Des Moines, IA Powell Chemical Dependency Center Dennis Weis, PI San Diego, CA South Bay Treatment Center Joseph Mawhinney, PI Kansas City, MO University of Missouri, Kansas City Services, Inc. Jan Campbell, PI Honolulu, HI John A. Burns School of Medicine & Queens Hospital William Haning, PI Methamphetamine Clinical Trials Group (MCTG) Los Angeles, CA UCLA Coordinating Center Richard Rawson, PI Division of Treatment Research & Development 19 September 2000

  30. MCTG Studies • Behavioral Platform Study (Completed Oct, 2002). (N=60) • Ondansetron Study ( Completed Dec 1, 2003. (N=120 • Bupropion Study (Completed June 1, 2005) (N=120) • Topirimate Study (Underway, projected completion, April 1, 2007 (N=120) • Modafinal Study (Projected to begin April 2007)

  31. MCTG: Accomplishments • Transferred state-of-the-art clinical trials methods to clinical sites with no previous research experience. • Successful conducted 3 studies to date with one (bupropion) showing significant promise • Sites now are capable of applying for independent research funding

  32. Process Improvement 101 Reduce Waiting & No-Shows  Increase Admissions & Continuation

  33. Why Process Improvement? • Customers are served by processes • 85% of customer related problems arecaused by organizational processes • To better serve customers, organizationsmust improveprocesses

  34. NIATx Four Project Aims Reduce Waiting Times Reduce No-Shows Increase Admissions Increase Continuation Rates

  35. NIATx Results Reduce Waiting Times:51% reduction (37 agencies reporting) Reduce No-Shows: 41% reduction (28 agencies reporting) Increase Admissions: 56% increase (23 agencies reporting) Increase Continuation: 39% increase (39 agencies reporting)

  36. Five Key Principles Evidence-based predictors of change • Understand & Involve the Customer • Focus on Key Problems • Select the Right Change Agent • Seek Ideas from Outside the Field and Organization • Do Rapid-Cycle Testing

  37. Understand and Involve the Customer • Most important of all the Principles • What is it like to be a customer? Staff are customers, too! • Walk-through, focus groups…

  38. Focus on Key Problems • What is keeping the executive director awake at night? • What processes have staff and customers identified as barriers to excellent service?

  39. Detour 1 Unclear purpose! • Where are you going? • How will you know you have arrived?

  40. Aim Statement • Example • Improve 30-day continuation rates from 30% to 80% in outpatient services. • Need • Target • Scope of work

  41. Detour 2 No feedback! • Need a tracking measure. • Have a simple measure.

  42. California’s Proposition 36:Did it Work?

  43. The Problem:California Prison Population, Drug Offenses, 1980-2000 Source: California Department of Corrections.

  44. Increase in California Prison Population, Drug Offenses, 1970-1999Rate per 100,000 Population Source: California Department of Corrections.

  45. Solutions?

  46. Proposition 36Substance Abuse & Crime Prevention Act (SACPA) • 2000 Ballot Measure: Passed by 61% of California voters in 2000 • Authorized $600,000,000 in new funds for implementation. 2001-2006. • Drug offenses: Non-sales, non-manufacturing. • Restrictions on offenders with histories of serious or violent crimes • Results in community supervision and treatment instead of: Incarceration or supervision without treatment

  47. 2000 Proposition 36 Ballot Wording: Proposition 36. Drugs. Probation and Treatment Program. Requires probation and drug treatment, not incarceration, for possession, use, transportation of controlled substances and similar parole violations, except sale or manufacture. Authorizes dismissal of charges after completion of treatment.

  48. Result 6,199,992 / 60.8% Yes votes 3,991,153 / 39.2% No votes Proposition 36 passed and was enacted as the: Substance Abuse & Crime Prevention Act (SACPA)

  49. Pipeline Arrest or Parole Violation Conviction and Court Order of Probation and Treatment; or Parole Referral Assessment Conviction Dismissed Treatment Completion Treatment (probation) Repeated No No No violation and petition, Ineligible shows shows petition dropouts denied Attrition

  50. ImplementationShow Rates

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