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Viral Inhibition of the Anaphase-Promoting Complex

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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death

Jose G. Teodoro, Ph.D

McGill Cancer Center

Department of Biochemistry

McGill University

Montréal, Canada

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Subunit structure of the APC/C

Thornton et al.

Genes & Dev (2006)

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Overview and future directions

How does G2/M arrest proceed to apoptosis?

Do current chemotherapies rely on APC/C inhibition for efficacy?

Can the APC/C be an anti-cancer drug target?

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Acknowledgements

McGill University

Isabelle Gamache

Mohamed Mustafa

Russell Towers

Sarah Assadian

Yiqing Lu

Michael Hell

U Mass

Michael Green

Destin Heilman

Albert Parker

Julie Zhou

Reagents

Frank Graham

Crister Hoog

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