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Clinical Cognitive Neuroscience Laboratory CCNL - Overview

Background of Main Line of Research. Previous research has suggested a dysfunctional magnocellular (M) visual pathway related to schizophrenia.Literature from basic vision research has demonstrated that diffuse red light suppresses activity in the M pathway.Initially shown with single-cell recording in monkeysLater inferred in humans via performance changes to M pathway tasks with a red background.

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Clinical Cognitive Neuroscience Laboratory CCNL - Overview

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    1. Clinical Cognitive Neuroscience Laboratory (CCNL) - Overview Director: Jeffrey S. Bedwell, Ph.D. Assistant Professor Clinical Ph.D. Program, Department of Psychology University of Central Florida

    2. Background of Main Line of Research Previous research has suggested a dysfunctional magnocellular (M) visual pathway related to schizophrenia. Literature from basic vision research has demonstrated that diffuse red light suppresses activity in the M pathway. Initially shown with single-cell recording in monkeys Later inferred in humans via performance changes to M pathway tasks with a red background

    3. Initial Findings – First-Degree Relatives of Persons with Schizophrenia

    4. Findings in First-Degree Relatives – fMRI with Red Light

    5. Aim of Current Study While this “red light effect” has been demonstrated in first-degree relatives – no published research as explored this effect in individuals with schizophrenia. Hypothesis: Individuals with schizophrenia will show the opposite reaction of accuracy in backward masking performance in response to a red, relative to green, background – as compared to controls.

    6. Demographics – Current Study Schizophrenia inpatients (N = 15) Age: mean = 39.59, SD = 10.87, range = 26 to 60 Gender: 12 males, 3 females Race: 10 Caucasian, 4 African American, 1 Hispanic/Latino Nonpsychiatric Controls (N = 16) Age: mean = 42.36, SD = 11.00, range = 24 to 60 Gender: 10 males, 3 females Race: 10 Caucasian, 3 African American, 2 Hispanic/Latino, 1 Asian

    7. Location Backward Masking Task

    8. Results

    9. Results from Schizotypy Sample

    10. Future Directions Explore whether green light actually helped to “fix” baseline M pathway hypoactivity in the schizophrenia participants. Addition of a third, gray, comparison background. Use event-related potentials (ERP) to explore the relative strength of M and P pathway activity within each color condition. Explore group differences Conduct heritability studies on this effect

    11. Other Research in Lab Olfaction and emotion processing in schizophrenia (Vidya Kamath) Cognition and emotion processing as related to delusion symptoms (Diana Orem) Neuropsychological correlates of social phobia (Scott Sutterby) Neuropsychological correlates of chronic stress in older adults (Diane Petrac) Two new grad students to focus on schizophrenia: Doug Dykstra and Andrew Deptula

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