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Fungus in pharmaceutical industries. تحت نظر: استادمحمد نسیم صدیقی. تهیه کنندگان: سکینه نایمن زینب ساعی حامدالدین صدیقی ذبیح الله محمدی اجمل یوسفی. The fungus being tested fungus demonstrates anti-bacterial activities Only a few very useful antibiotics were discovered in fungi

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fungus in pharmaceutical industries

Fungus in pharmaceutical industries

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slide3
تحت نظر: استادمحمد نسیم صدیقی

تهیه کنندگان:

سکینه نایمن

زینب ساعی

حامدالدین صدیقی

ذبیح الله محمدی

اجمل یوسفی

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The fungus being tested

  • fungus demonstrates anti-bacterial activities
  • Only a few very useful antibiotics were discovered in fungi
  • With the mass production of penicillin, there began a search for antibiotics from other fungi, bacteria and algae.

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penicilluim notatum
Penicilluim notatum
  • Penicillin is the liquid which is secreted from penicillium notatum, which is the mold.

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Penicillin is one antibiotic that kills bacteria. It is produced by Penicillium chrysogenum and related species.

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1945 :Alexander Fleming noticed that a mold (penicillium notatum) produced a compound that inhibits bacterial growth.

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The fungus was eventually identified to be Penicillium notatum.

  • Although similar to lysozyme action, penicillin was far more powerful an antibacterial compound. Flemings' crude extracts could be diluted 1,000 times and still was effective in killing bacteria and not toxic to animals.

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There are many species of Penicillium. A

  • Penicillium chrysogenum was found to
  • 200 times more than P. notatum.

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Then in 1939, Sir Howard Florey

  • Sir Ernest Chain

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cephalosporium acremonium
Cephalosporium Acremonium
  • Cephalosporins are another class of antibiotics produced by Cephalosporium acremonium and related species

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First discovered from Acremonium chrysogenum in 1953.

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Cephalosporin has also been identified from other fungi such as Emericellopsis and Paecilomyces, two genera that are morphologically similar to Penicillium.

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economic importance of cephalosporins
Economic Importance of Cephalosporins
  • Cephalosporin is one of the most widely used antibiotics, and economically speaking, has about 29% of the antibiotic market.

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streptomyces griseus
Streptomycesgriseus

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Spore arrangement in Streptomyces griseus. Grey spores arranged in straight chains, as is typical of these strains.

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The discovery of streptomycin, an anti-tuberculosis antibiotic

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penicillium griseofulvum
Penicilliumgriseofulvum
  • Griseofulvin was first isolated from.
  • mutated strain of P. patulum

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fungal antibiotic

  • infections of hair, nail, skin and athlete's foot and ringworm.
  • a fungistatic antibiotic..

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claviceps purpurea
Clavicepspurpurea

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claviceps purpurea1
Clavicepspurpurea
  • Fungi have been used medicinally since ancient times.
  • Ergotamine,
  • is used to facilitate delivery of babies
  • relieve migraine headaches

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scientific classification
Scientific classification
  • Kingdom: Fungi
  • Division: Ascomycota
  • Class: Sordariomycetes
  • Subclass: Hypocreomycetidae
  • Order: Hypocreales
  • Family: Clavicipitaceae
  • Genus: Claviceps

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rhizopus nigricans
Rhizopusnigricans

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scientific classification1
Scientific classification
  • Kingdom: FungiDivision: ZygomycotaClass: ZygomycetesOrder: MucoralesFamily: MucoraceaeGenus: Rhizopus

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The steroids in "the pill" are produced industrially by a fungus,

  • as are the steroids cortisone and prednisolone.

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tolypocladium inflatum
Tolypocladiuminflatum

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If you've had an organ transplant you might be taking Cyclosporin

  • immunosuppressant

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aspergillus nidulans
Aspergillusnidulans

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Cilofungin

  • It is not the natural product extracted from fungi.
  • The antibiotic is developed from a metabolite extracted from several species of Aspergillus such as A. nidulans and A. rugulosus.
  • It is thus a semi-synthetic antibiotic.

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economic importance of cilofungin
Economic Importance of Cilofungin
  • Cilofungin is specifically developed to treat candiasis (which commonly manifests as thrush) caused by the fungus Candida albicans.

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ganoderma lucidum
Ganodermalucidum

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ganoderma lucidum1
Ganodermalucidum
  • یكی از قارچهای با خاصیت دارویی است كه بیش از 4000 سال در طب سنتی چین و ژاپن استفاده می‌شده است. مردم چین قارچ گانودرما را گیاهی از جانب خداوند دانسته‌اند كه می‌تواند به عنوان اكسیری از ابدیت، سلامتی و آسایش انسانها را تضمین كند(2). در طب سنتی قارچ گانودرما در درمان ضعف و كوفتگی‌های عمومی بدن، تنگی نفس،‌ بیخوابی و سرفه‌ها استفاده می‌شد(3). مطالعات و تحقیقات نوین به‌طور روز افزون، آن باورها و عقاید را تایید كرده و اغلب مطالعات جدید خاصیت دارویی این قارچ را هم اکنون در زمینه كاهش فشار خون، كاهش چربی خون، حفاظت از كبد، ضد التهاب، ضد دیابت، فعالیتهای ضد میكروبی، هپاتیت،‌معده درد، ارتروز، برنشیت، ورم معده، تنگی نفس، بی اشتهایی، ورم كلیه و سرطانها مورد تایید قرار داده است(4). در حال حاضر این قارچ به‌صورت تجاری در شمال آمریكا،‌ چین،‌ تایوان،‌ ژاپن و كره جنوبی كشت می‌شود.

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slide34

Many tnx

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