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Some Bodies in the Brain: A Diagnostic Conference

Join Dr. Ronald L. Hamilton, Associate Professor of Neuropathology at the University of Pittsburgh, as he identifies and discusses various types of "bodies" that populate neuropathology. This conference will cover topics such as psammoma bodies, Verocay bodies, eosinophilic granular bodies, Negri bodies, and more.

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Some Bodies in the Brain: A Diagnostic Conference

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  1. “SOME BODIES IN THE BRAIN”Noon Diagnostic Conference11-20-2003 Ronald L. Hamilton, M.D. Associate Professor of Neuropathology, University of Pittsburgh

  2. Some Bodies in the Brain Identify these “bodies” that populate neuropathology

  3. Psammoma bodies

  4. Verocay body

  5. Eosinophilic Granular Bodies (EGB)

  6. Negri bodies

  7. Cortical Lewy Body

  8. Round basophilic inclusion #1 (Pick body vs. mnd inclusion body)

  9. Round basophilic inclusion #2 (Pick body vs. mnd inclusion body)

  10. Bunina bodies

  11. Corpora amylacea

  12. PAS stain Lafora body (polyglucosan body)

  13. Hirano body

  14. Granulovacuolar degeneration (Simchowicz bodies)

  15. Marinesco body

  16. Herring bodies

  17. Buscaino bodies (mucocytes)

  18. Zebra bodies

  19. Fingerprint bodies

  20. Psammoma bodies Psammoma bodies: meningioma

  21. Psammoma bodies Derived from meningothelial whorls Psammomatous meningioma spinal cord (females)

  22. Psammoma bodies melanotic Schwannomas - 50% are psammomatous half of melanotic psammomatous Schwannomas have Carney complex Auto dominant mutation in Protein kinase A holoenzyme lentiginous facial pigmentation cardiac myxoma, calcifying Sertoli cell tumors endocrine overactivity Cushing syndrome multinodular adrenal hyperplasia acromegaly - pituitary adenoma

  23. Verocay bodies Schwannoma Antoni A areas Infrequent in acuostic and cellular Schwannomas

  24. Verocay bodies Bilateral acoustic schwannomas = NF II autosomal dominant 22q12 - merlin (schwannomin) similar to cytoskeletal proteins moesin, ezrin, radixin (MER) +meningiomas, spinal ependymomas, posterior lens opacities, meningioangiomatosis

  25. Eosinophilic Granular Bodies (EGB) Gangliogliomas, Pilocytic Astrocytomas, Pleomorphic Xanthoastrocytoma Degenerating tumor astrocytes PAS-positive

  26. Eosinophilic Granular Bodies (EGB)

  27. Eosinophilic Granular Bodies (EGB) I

  28. Negri bodies Rabies encephalitis Purkinje cells, CA-1 hippocampus >10,000 human deaths per year

  29. Negri bodies

  30. Lewy bodies Parkinson’s Disease DLB, LBVAD, MSA, age

  31. Lewy bodies May be multiple

  32. Lewy bodies Cortical Lewy bodies Entorhinal cortex, cingulate gyrus, insular cortex, other neocortex

  33. Lewy bodies Cortical LB can be difficult to detect on H&E Strongly ubiquitin-positive (vs. globose NFT)

  34. Lewy bodies Alpha-synuclein positive, specific and sensitive

  35. Lewy bodies Hyaline bodies are abnormal aggregates of AS May be precursor to LB

  36. Pick bodies Pick’s disease Fronto-temporal dementia Severe neuronal loss and gliosis (“knife-edge” atrophy) Neocortex, dentate gyrus

  37. Pick bodies Strongly argyrophilic (silver stains - Bielschowsky, Bodian) ++tau, +ubiquitin +/- Pick cells (balloon cells) EM-straight filaments Tau Pick cell

  38. MND-inclusion bodies Motor Neuron Disease (MND) inclusion body ALS, ALS with dementia or aphasia FTD (mnd-inclusion body dementia), Primary progressive aphasia Superficial neocortex, dentate gyrus NOT IN MOTOR NEURONS

  39. MND-inclusion bodies ubiquitin Negative silver stain Ubiquitin positive Negative for tau and alpha-synucelin Composition unknown ubiquitin

  40. Pick bodies vs. mnd-inclusion bodies Pick I Tau MND-inclusion ubiquitin Bielschowsky

  41. Bunina bodies Lower motor neurons ALS Unknown composition

  42. ALS - other LMN inclusions Hyaline bodies Ubiquitin skeins

  43. Corpora amylacea Subpial and perivascular most common location

  44. Corpora amylacea Increased with age, Neurodegeneration. Olfactory bulb, base of brain, spinal cord Astrocytic inclusion

  45. Corpora amylacea PAS-positive and ubiquitin-positive Ubiq PAS

  46. Lafora Bodies Lofora Body Disease Polyglucosan Body Disease Myoclonic epilepsy Autosomal recessive Intraneuronal inclusions Liver biopsy

  47. Hirano bodies Hippocampus CA-1, subiculum Neuronal cytoplasmic inclusion Actin and actin-related proteins Non-specific Increased with age esp. with AD

  48. Hirano bodies

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