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Bioavailibility and Effect on Lipid Metabolism of Crude β- Carotene Extract from Sweet Potato Leaves and Synthetic β- Carotene in Rats Fed Different High Fat Diets. Recently clinical trials indicate that an increasing relative risk of death from cardiovascular disease following

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Bioavailibility and Effect on Lipid Metabolism of Crude β- Carotene Extract from Sweet Potato Leaves and Synthetic β- Carotene in Rats Fed Different High Fat Diets

  • Recently clinical trials indicate that an increasing relative

  • risk of death from cardiovascular disease following

  • synthesized beta-carotene supplement. We are

  • interested in the problem whether synthetic beta-carotene is

  • suitable for use as a dietary supplement. The purpose of

  • this study was to investigate the effects of different

  • sources of beta-carotene and lipids on lipid metabolism and

  • beta-carotene availability in rats. Forty adult male Wistar

  • rats were randomly divided into five groups with the

  • variables including the sources the sources of beta-carotene

  • (synthetic and natural beta-carotene crude extract from sweet

  • potato leaves ) and lipids (soybean oil and lard ). Diets and

  • water were given ad libitum, and was 10g/kg cholesterol

  • added in diets for forty days. The results showed that for

  • (-carotene concentration in the serum and liver, the

  • synthetic (-carotene groups were significantly higher

  • than the beta-carotene extract groups (P<0.05). Comparison of

  • the effect of different lipids under the same beta-carotene

  • source indicated that, the lard groups were

  • significantly higher in beta-carotene concentration than the

  • soybean oil groups. Different sources of beta-carotene

  • and lipid fed did not affect the serum and liver retinol

  • concentration in both the soybean oil-fed groups and the lard-

  • fed groups (P>0.05). The effects on lipid metabolism

  • were as follows: The synthetic beta-carotene groups had

  • significantly higher ratio between high density lipoprotein

  • cholesterol (HDL-C) and low density lipoprotein

  • cholesterol (LDL-C) than the beta-carotene extract

  • groups (P<0.05), the beta-carotene extract groups is the most

  • significant. Besides, the synthetic beta-carotene groups

  • and the beta-carotene extract groups could both cause liver


Bioavailibility and Effect on Lipid Metabolism of Crude β- Carotene Extract from Sweet Potato Leaves and Synthetic β- Carotene in Rats Fed Different High Fat Diets

  • total cholesterol content decreasing, and the beta-carotene

  • extract groups is the most significant. The synthetic beta-

  • carotene groups serum and liver acyltriglyceride

  • concentration are significant higher than the beta-carotene

  • extract groups. The rat serum, liver and adrenal gland beta-

  • carotene concentration in the synthetic beta-carotene

  • groups are all the lard group significant higher than the

  • soybean oil group. Under the injection of soybean oil, the beta-

  • carotene extract group serum and liver acyltriglyceride

  • concentration are significant lower than the synthetic

  • beta-carotene group, but the groups under the lard injection are

  • not statistically different. The effects on fatty acid

  • were as follows: Among the soybean oil groups, the

  • serum and liver linoleic acid (18:2,n-6) ratios were

  • significantly higher in the synthetic beta-carotene groups than

  • in the beta-carotene extract groups (P<0.05); and Among the

  • lard groups the serum and liver oleic acid (18:1,n-9)

  • ratios were significantly higher in the synthetic beta-carotene

  • groups than in the beta-carotene extract groups (P<0.05).

  • These results suggest that ingestion of beta-carotene

  • crude extract from sweet potato leaves, as compared to

  • injestion of the synthetic beta-carotene, has the benefit of

  • decreasing serum lipids. Except this, the lard diet could

  • cause more beta-carotene deposit in the liver and increase

  • beta-carotene bioavailability.


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