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Translational Sciences: Purdue Resources

Translational Sciences: Purdue Resources. Charles Buck Director of Operations Bindley Bioscience Center cbuck@purdue.edu 765-494-2208. Support for Success. Interdisciplinary team approach Entrepreneurial driven culture Administrative, business and scientific support

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Translational Sciences: Purdue Resources

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  1. Translational Sciences: Purdue Resources Charles Buck Director of Operations Bindley Bioscience Center cbuck@purdue.edu 765-494-2208

  2. Support for Success • Interdisciplinary team approach • Entrepreneurial driven culture • Administrative, business and scientific support • Seed grants for promising research • State-of-the-art research facilities and equipment

  3. Discovery Park • Integrated core centers: • Nanotechnology • Bioscience • Entrepreneurship • Learning • Regenstrief Center for Healthcare engineering • Oncological sciences • ACCESS – computation • Sustainability (GSI) Burton D. Morgan Center for Entrepreneurship Gerald D. and Edna E. Mann Hall Birck Nanotechnology Center Bindley Bioscience Center Discovery Learning Research Center Infrastructure • Administrative • Business team – SPS & business office • Project coordination • Web site integration • Special events • Technical • Research Cores – partnership with academic units • Equipment and facilities Project research centers and subcenters

  4. Mass Spec profiling informatics

  5. Proteomics enabling longitudinal studies Evaluate patient samples at baseline and 15 months “Consistency of the platform enabled profiling of discrete human plasma samples comprising the largest human proteomic profile dataset to date. All of these data are available publicly for independent analysis and provide a resource for plasma protein biomarker discovery and verification.” healthy 15 mo cancer patients baseline cancer patients

  6. Micro SPECT / CT Imaging MiLabs U-SPECT-II/CT • Combined SPECT and x-ray CT Enables SPECT and CT image registration • Multi-pinhole collimators High resolution imaging (350 um voxels) High sensitivity imaging (kBeq source) • Data binning relative to biological rhythms Reduces blur • List mode acquisition and statistical 3-D image reconstruction algorithm. Improves image quality

  7. Purdue Translational Pharmacology Superior approach for in vivo pharmacokinetics and pharmacodynamics Norepinephrine concentrations during automated (Culex-L) and manual (jugular stick) blood sampling Culex-L at work

  8. Animal models & preclinical studies • Full service histology laboratory. Two board certified veterinary pathologists available for collaboration. • The vet Clinical Trials Group provides the expertise & facilities for animal clinical trials (veterinary) & translational preclinical investigation (human) • The Clinical Discovery Lab provides for: • analysis and testing of orthopedic /biomedical devices • experimental surgery Terrier bladder cancer model

  9. Body composition, diet, disease Indirect calorimetry Body plethysmography Ingestive behavior

  10. Camp Calcium • Gain valuable information about bone health in adolescents to help other children build strong bones in the future. • Ethnic group participation • Campers are educated about nutrition and bone health. Faculty: Dr. Connie Weaver

  11. Electrical, mechanical, optical, acoustical devices and instruments Nano, micro, macro design and fabrication Both diagnostic and therapeutic (e.g., bionano) device/protocol development Diverse application areas (neurological, cardiovascular, orthopedic, cancer) Links to Indiana medical device companies Extensive benchtop device testing capabilities Preclinical study planning expertise BME/Nano Capabilities Nano Fab in Birck MRI research/patient center

  12. Tethered Nanocube-Carbon Nanotube Biosensor Performance Enhanced SEM image of the Au/Pd nanocube augmented single walled carbon nanotube (CNT) network glucose sensors. Comparison with other available technologies Drs. D. Marshall Porterfield and Tim Fisher

  13. SpeechVive™ Unobtrusive portable device designed to improve speech and communication in patients with PD Uses the Lombard Effect, preserved in patients with PD, to elicit louder and clearer speech spontaneously Designed and built by CTSI biomedical/bionanotechnology team Faculty: Dr. Jessica Huber • OTC licensed to AMIPurdue as a development partner • Design and engineer productization of prototype • Support to positioning device for FDA submission

  14. Alfred E. Mann Institute Purdue • The Institute provides comprehensive – • Intellectual Property Analysis and Development • Market Analysis • Regulatory Pathway Planning • Reimbursement Strategies • Clinical Application Assessment • Product Development Process • Business Modeling • Licensing Strategies • Project Selection • Product Launch Strategies • Quality System Implementation • Technical Feasibility Study • Industrial Design • Product Requirement Specification • Clinical Studies • Manufacturing Process Validation • Competitive Analysis • Exit Strategies - created by a $100 million endowment from the non-profit Alfred E. Mann Foundation for Biomedical Engineering (AEMFBE)

  15. Office of Technology Commercialization Nurture Innovation: Trask Innovation Fund 98 innovations Nanoscale investment: ave. $48,000 TIF investments yielded 89 separate commercial licenses TIF supported innovations are licensed at a 45% increase relative to technologies supported by federal funding alone

  16. Office of Technology Commercialization Nurture Innovation: Emerging Innovation Fund Established 2008, seeded by PRF makes a relative microscale investment in select Purdue-related new ventures. Leverage EIF investment to obtain macroscale funding from non-dilutive sources (SBIR, STTR) or institutional investor

  17. University – business collaboration

  18. CY2009: Deal Flow

  19. Thank you for your attention! cbuck@purdue.edu

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