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Kevin S. Williamson Yoon Group April 9, 2009. Dolbier Jr., W.R. Journal of Fluorine Chemistry 2005 , 126, 157-163 US Patent 2230654. 2. 3. Dolbier Jr., W.R. Journal of Fluorine Chemistry 2005 , 126, 157-163. Dolbier Jr., W.R. Journal of Fluorine Chemistry 2005 , 126, 157-163

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Kevin S. Williamson

Yoon Group

April 9, 2009

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Dolbier Jr., W.R. Journal of Fluorine Chemistry 2005, 126, 157-163

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Dolbier Jr., W.R. Journal of Fluorine Chemistry 2005, 126, 157-163

O’Hagan et al. Nature 2004, 427, 561-565

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Fried, J.H.; Sabo, E.F. JACS 1953, 75, 2273-74

Fried, J.H.; Sabo, E.F. JACS1954, 76, 1455-56

5

slide6

H.-J. Böhm et al. ChemBioChem 2004, 5, 637-643

Kirk, K.L. Organic Process Research and Development 2008, 12, 305-321

6

slide7

H.-J. Böhm et al. ChemBioChem 2004, 5, 637-643

M.A. Massa et al. Bioorganic and Medicinal Chemistry Letters 2001, 11, 1625-28

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H.-J. Böhm et al. ChemBioChem 2004, 5, 637-643

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R = H R = F

H.-J. Böhm et al. ChemBioChem 2004, 5, 637-643

Boehm et al. J. Med. Chem. 1996, 39, 3929-3937

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Tygon & Teflon

Tubing

5% F2 in N2

NaF(s)

KI traps

N2

REACTOR

Purrington, S.T.; Woodard, D.L. JOC 1991, 56, 142

Wong et al. ACIE 2005, 44, 192-212

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Wong et al. ACIE 2005, 44, 192-212

R.E. Banks, US Patent 5,086,178

11

slide12

12

Differding, E.; Lang, R.W.; TL 1988, 29, 6087-6090

slide13

13

Shibata, N.; Suzuki, E; Takeuchi, Y. JACS 2000, 122, 10728-10729

slide14

14

Hintermann, L.; Togni, A. ACIE 2000, 39, 4359-4362

slide15

15

Shibata et al.ACIE 2005, 44, 4204-4207

slide16

Beeson, T.D.; MacMillan, D.W.C.; JACS 2005, 127, 8826-8828

Steiner, D.D; Mase, N.; Barbas III, C.F.; ACIE 2005, 44, 3706-3710

16

slide17

17

Jørgensen et al. ACIE 2005, 44, 3703-3706

slide18

18

Jørgensen et al. ACIE 2005, 44, 3703-3706

slide19

19

Jørgensen et al. ACIE 2005, 44, 3703-3706

slide20

Bruns, S.; Haufe, G. Journal of Fluorine Chemistry 2000, 104, 247-254

Togni et al. Eur. J. Inorg. Chem. 2006, 1397-1412

20

slide21

Ferraris, J.P.; Saito, G. J. Chem. Soc. Chem. Commun. 1979, 914

Suzuki, H.; Kimura, Y. J. Fluorine Chem. 1991, 52, 341-351

21

slide22

22

Hull, K.L.; Anani, W.Q.; Sanford, M.S. JACS2006, 128, 7134-7135

slide23

23

Ball, N.D.; Sanford, M.S. JACS2009, 131, 3796-97

slide24

24

Ball, N.D.; Sanford, M.S. JACS2009, 131, 3796-97

slide25

25

Furuya, T.; Kaiser, H.M.; Ritter, R. ACIE 2008, 47, 5993-5996

slide26

26

Furuya, T.; Ritter, T. JACS2008, 130, 10060-10061

slide27

27

Furuya, T.; Strom, A.; Ritter, T. JACS 2009, 131, 1662-1663

slide28

28

Furuya, T.; Strom, A.; Ritter, T. JACS 2009, 131, 1662-1663

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Phelps, M.E. PNAS 2000, 97, 9226-9233

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Top

Bottom

Prostate Cancer

Breast Cancer

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Phelps, M.E. PNAS 2000, 97, 9226-9233