Abstract. Modern chemotherapy has played a major role in our control of tuberculosis. Yet tuberculosis still remains a leading infectious disease worldwide (persistence of tubercle bacillus and inadequacy of the current chemotherapy.)
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Yet tuberculosis still remains a leading infectious disease worldwide (persistence of tubercle bacillus and inadequacy of the current chemotherapy.)
How our current drugs work and the need to develop new and more effective drugs.
1.A brief historical account of tuberculosis drugs
2.Examines the problem of current chemotherapy
3.Discusses the targets of current tuberculosis drugs
4.Focuses on some promising new drug candidates
5.Proposes a range of novel drug targets for intervention.
Addresses the problem of conventional drug screens based on inhibition of replicating bacilli
The challenge to develop drugs that target nonreplicating persistent bacilli.
A new generation of drugs (target persistent bacilli is needed for more effective treatment of tuberculosis.)
largely owing to HIV infection, immigration, increased trade, and globalization