20 likes | 31 Views
The development of a spray-drying process has been traditionally empirical and <br>experimental. Traditional approaches typically involve iterative design of experiments <br>(DOE), statistical treatment of process parameters, and large API samples. <br>Unfortunately, these methods often result in poorly understood processes. Recently, <br>several attempts have been made to develop fundamental models that can help <br>understand the spray drying process. Models range from equilibrium-based to <br>steady-state approaches. Computational fluid dynamics can also be used to describe <br>the spray-drying process.
E N D
Improve Efficiency and Improve Productivity With a Spray Drying Process The development of a spray-drying process has been traditionally empirical and experimental. Traditional approaches typically involve iterative design of experiments (DOE), statistical treatment of process parameters, and large API samples. Unfortunately, these methods often result in poorly understood processes. Recently, several attempts have been made to develop fundamental models that can help understand the spray drying process. Models range from equilibrium-based to steady-state approaches. Computational fluid dynamics can also be used to describe the spray-drying process. The inlet and outlet air temperatures of the spray drying process are measured with PT100s from Contec. The temperature of the air inlet was compared to the outlet air temperature to estimate absolute moisture. This information was used to calculate the yield of the process. The results from this study can be used to help improve the efficiency of spray drying processes for food, pharmaceuticals, and other products. The spray drying process was found to be effective when used in conjunction with a dry bulb temperature. In a traditional QbD approach, the process is linked to the formulation. Key quality attributes (KQAs) and critical process parameters (CQAs) are identified and compared. These key attributes are then used to identify and prioritize the spray-drying process parameters that will maximize the desired KQAs and minimize the impact on CQAs. It is important to note that the process used during the development of a dry powder has the same degree of control as that of a solvent-free solution. In a continuous and fully automated process, the spray-drying process can transform a liquid material into a powder. In addition, it is highly versatile and can be used for a variety of food types, including heat-sensitive and heat-resistant substances. The
process can use many feed materials, and feed materials are typically pumpable. A recent innovation in the spray drying process may open the door to novel drug delivery systems and formulations. Experienced professionals can help you optimize the process for your unique needs. The spray drying process has advanced tremendously in the last 30 to 50 years. The technique has the potential to improve the efficiency of drying and increase profits. The technique can be used in lab settings as well as in large industrial factories producing dozens of tons of material per hour. It produces a powder with adjustable granulometry, which increases its properties and ease of handling. When it comes to encapsulation, the process is extremely versatile and streamlined compared to other methods.