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Canary Courtship The Story of Neurogenesis. with Susan Wehry, M.D. . Images of Aging. Images of Aging. STOP AGING NOW!. AGE WELL NOW. The brain can’t make new cells, RIGHT?. WRONG. What’s new about being old?. Neuronal plasticity Variability Modifiability. Genesis…Neuro style.

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Presentation Transcript
images of aging3
Images of Aging

STOP AGING NOW!

AGE WELL NOW

what s new about being old
What’s new about being old?
  • Neuronal plasticity
  • Variability
  • Modifiability
the songbird story
The Songbird Story
  • Fernando Nottenbohm
  • 1980’s, Rockefeller University
  • Song center  spring
  • Hippocampus  fall
the songbird skeptics
The Songbird Skeptics
  • Restricted throughout evolution
  • New neurons would disrupt
  • No primate neurogenesis
the primate story
The Primate Story
  • Elizabeth Gould
  • Bruce McEwen
  • Hippocampus
    • Tree shrew
    • Marmoset
    • Rhesus monkey
  • Neocortex
the human story
The Human Story
  • Fred Gage
  • Cancer patients
  • Neurogenesis
    • human hippocampus
do they work
Do they work?
  • Enriched environments 
      • heavier brains
      •  synapses
      •  branching
      •  learning

Even in very old mice

neurogenesis
Neurogenesis
  • Stimulated by
    • Enriched environments
      • toys and friends
    • Participation in learning
    • Physical exercise
neurogenesis13
Neurogenesis
  • Inhibited by
    • Isolation
    • Stress
the aging brain
The Aging Brain
  • Knowledge in transition
  • Tremendous variation
    • Within the brain
    • Between individuals
components
Components

Dendrites

Cell body

Synapse

Axon

neurons
Neurons

100,000,000,000

ONE HUNDRED BILLION

synapses
Synapses

10,000s /neuron

104 X 1011

=

1,000,000,000,000,000

slide19

ONE

Quadrillion

the brain responds
The Brain responds
  • Neurogenesis
  • Synapses reorganize
  • Dendrites sprouting
the human hippocampus
The Human Hippocampus
  • Main relay station
    • New memory
      • Long term storage
      • Discard
the human hippocampus23
The Human Hippocampus
  • London Taxi Drivers
    • Enlarged
    • Right activated routes
  • Dementia, Alzheimer’s type
    • Smaller volume
the aging brain24
The Aging Brain
  • Decrease in brain weight
    • Plasticity >  Neurons
  • Function
    • Less efficient
    • Slower rate
    • No change in total learning
  • Modifiable
successful aging
Successful Aging
  • MacArthur Foundation
    • Genetic factors < 50%
    • Education strongest predictor
  • Health
    • Physical/mental
  • Optimism/Self-efficacy
  • Social support
barriers to successful aging
Barriers to successful aging

As we age, our expectations change:

  • we demand less and less of our brains
  • we link our absentmindedness to age
  • we accept ageist stereotypes
remove the barriers
Remove the Barriers
  • Alter expectations
  • Develop a strategy
take stock
Take Stock
  • Illness inventory
  • Health inventory
  • Stress inventory
change behavior
Change Behavior
  • Make a pledge
  • Identify goal
  • Visualize undertaking
change behavior31
Change Behavior
  • Plan for success
  • Set up a routine
  • Engage a partner
  • Get started
exercise

EXERCISE

BODY

BRAIN

practice

PRACTICE

Remembering

Thinking

Problem-solving

strategies
Strategies
  • Maintain health
    • Physical
    • Mental
  • Stay connected
  • Active life style
  • Nutrition
  • Enrich environment
you heard it here
You heard it here!
  • Use it or lose it

“That which is used develops,

that which is not used,

wastes away”

(Hippocrates 460-337 B.C.)

you heard it here36
You heard it here!
  • Story of neurogenesis
  • Knowledge
    • aging human brain
    • successful aging
  • Strategies
you heard it here37
You heard it here!
  • Alter expectation
  • Remember mama
  • Stay connected
to learn more or just to stay in touch

To learn more or just to stay in touch

Please visit my website

www.susanwehrymd.com

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